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首页> 外文期刊>Cytokine >Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey
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Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey

机译：自闭症谱系疾病中的细胞因子表达谱：土耳其的多中心研究

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摘要

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in communication and social interaction as well as restricted interests and repetitive behaviors. The pathogenesis of ASD is not completely understood, but a growing body of research has demonstrated that the immune response may be a contributing factor in the etiology and/or ontogeny of ASD. The aim of this study was to determine the expression levels of IL-1 beta, IL-1 alpha, IL-4, IL-6, IL-17, TNF-alpha and TGF-beta in peripheral blood mononuclear cells of children with ASD and healthy controls in order to determine the contributions of cytokines to ASD. Within the study timeframe, 195 children with ASDs (80.5% male) and 162 controls (73.6% male) were enrolled. Most children with ASD had a comorbid disorder (n = 114, 58.5%), with the most common diagnoses as Intellectual Developmental Disorder (IDD, n = 64, 32.8%) and ADHD (n = 64, 32.8%). The majority of children with ASD had severe autistic symptoms as evaluated via Childhood Autism Rating Scale (CARS, n = 130, 64.6%). The mean CARS score in the ASD sample was 40.8 (S.D. = 7.6). The patients with ASD were found to have significantly higher levels of IL-6 (p < 0.001) and significantly lower levels of IL-17 (p < 0.05, all Bonferroni corrected). Treatment tended to affect IL-4 levels. Lastly, discriminant function analysis (DFA) revealed that a combination of IL-6, IL-17 and IL-1 alpha correctly classified 56.6% of cases. Despite extensive immunological evidence suggesting immune system aberrations, further research is required to clarify the relationship between immune profiles and ASD symptoms.
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  • 来源
    《Cytokine》 |2020年第1期|共8页
  • 作者

    Kutuk Meryem Ozlem; Tufan Evren; Gokcen Cem; Kilicaslan Fethiye; Karadag Mehmet; Mutluer Tuba; Yektas Cigdem; Coban Nurdan; Kandemir Hasan; Buber Ahmet; Coskun Seyma; Acikbas Ufuk; Guler Gulen; Topal Zehra; Celik Fatma; Altintas Ebru; Giray Asli; Aka Yeliz; Kutuk Ozgur;

  • 作者单位

    Baskent Univ Dr Turgut Noyan Med &

    Res Ctr Dept Child &

    Adolescent Psychiat Adana Turkey;

    Acibadem Mehmet Ali Aydinlar Univ Dept Child &

    Adolescent Psychiat Istanbul Turkey;

    Gaziantep Univ Dept Child &

    Adolescent Psychiat Gaziantep Turkey;

    Mehmet Akif Inan Educ &

    Res Hosp Dept Child &

    Adolescent Psychiat Sanliurfa Turkey;

    Mardin State Hosp Dept Child &

    Adolescent Mardin Turkey;

    Koc Univ Dept Child &

    Adolescent Psychiat Istanbul Turkey;

    Duzce Univ Dept Child &

    Adolescent Psychiat Duzce Turkey;

    Sanliurfa Educ &

    Res Hosp Dept Child &

    Adolescent Psychiat Sanliurfa Turkey;

    Celal Bayar Univ Dept Child &

    Adolescent Psychiat Manisa Turkey;

    Pamukkale Univ Dept Child &

    Adolescent Psychiat Denizli Turkey;

    Mersin State Hosp Dept Child &

    Adolescent Psychiat Mersin Turkey;

    Oxford Brookes Univ Dept Hlth &

    Life Sci Oxford England;

    Mersin Univ Dept Child &

    Adolescent Psychiat Mersin Turkey;

    Gaziantep Univ Dept Child &

    Adolescent Psychiat Gaziantep Turkey;

    Malatya State Hosp Dept Psychol Malatya Turkey;

    Baskent Univ Dept Psychiat Dr Turgut Noyan Med &

    Res Ctr Adana Turkey;

    Alanya Alaaddin Keykubat Univ Dept Genet &

    Bioengn Alanya Turkey;

    Baskent Univ Adana Dr Turgut Noyan Med &

    Res Ctr Dept Immunol Adana Turkey;

    Baskent Univ Adana Dr Turgut Noyan Med &

    Res Ctr Dept Immunol Adana Turkey;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Autism Spectrum Disorder; Cytokines; Immune system; Inflammation;

    机译：自闭症谱系;细胞因子;免疫系统;炎症;

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