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首页> 外文期刊>Cytoskeleton >Proper cytoskeleton alpha-tubulin distribution is concomitant to tyrosine phosphorylation duringin vitrocapacitation and acrosomal reaction in human spermatozoa
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Proper cytoskeleton alpha-tubulin distribution is concomitant to tyrosine phosphorylation duringin vitrocapacitation and acrosomal reaction in human spermatozoa

机译：适当的细胞骨架α-微管蛋白分布伴随着抗腐蚀和人体精子的仿臼瘤和拟囊体反应期间的酪氨酸磷酸化

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摘要

Spermatozoa motility is a key parameter during the fertilization process. In this context, spermatozoa tyrosine protein phosphorylation and an appropriate cytoskeleton alpha-tubulin distribution are some of the most important physiological events involved in motility. However, the relationship between these two biomarkers remains poorly defined. Here, we characterized simultaneously by immunocytochemistry the alpha-tubulin (TUBA4A) distribution and the tyrosine phosphorylation at flagellum before capacitation, during different capacitation times (1 and 4 hr), and after acrosome reaction induction in human spermatozoa. We found that the absence of spermatozoa phosphorylation in tyrosine residues positively and significantly correlated (p < 0.05) with the terminal piece alpha-tubulin flagellar distribution in all physiological conditions. Conversely, we observed a positive significant correlation (p < 0.01) between phosphorylated spermatozoa and continuous alpha-tubulin distribution in spermatozoa flagellum, independently of the physiological condition. Similarly, the subpopulation of spermatozoa with tyrosine phosphorylated and continuous alpha-tubulin increases with longer capacitation times and after the acrosome reaction induction. Overall, these findings provide novel insights into the post-transcriptional physiological events associated to alpha-tubulin and the tyrosine phosphorylation during fertilization, which present potential implications for the improvement of spermatozoa selection methods.
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