Divergent roles of β‐ and γ‐actin isoforms during spread of vaccinia virus

Marzook N. Bishara; Latham Sharissa L.; Lynn Helena; Mckenzie Christopher; Chaponnier Christine; Grau Georges E.; Newsome Timothy P.

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Divergent roles of β‐ and γ‐actin isoforms during spread of vaccinia virus

机译：β-和γ-肌动蛋白同种型在痘苗病病毒蔓延期间的发散作用

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Abstract Actin is a major component of the cytoskeleton and is present as two isoforms in non‐muscle cells: β‐ and γ‐cytoplasmic actin. These isoforms are strikingly conserved, differing by only four N‐terminal amino acids. During spread from infected cells, vaccinia virus (VACV) particles induce localized actin nucleation that propel virus to surrounding cells and facilitate cell‐to‐cell spread of infection. Here we show that virus‐tipped actin comets are composed of β‐ and γ‐actin. We employed isoform‐specific siRNA knockdown to examine the role of the two isoforms in VACV‐induced actin comets. Despite the high level of similarity between the actin isoforms, and their colocalization, VACV‐induced actin nucleation was dependent exclusively on β‐actin. Knockdown of β‐actin led to a reduction in the release of virus from infected cells, a phenotype dependent on virus‐induced Arp2/3 complex activity. We suggest that local concentrations of actin isoforms may regulate the activity of cellular actin nucleator complexes.

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来源
《Cytoskeleton》 |2017年第4期|共14页
作者
Marzook N. Bishara; Latham Sharissa L.; Lynn Helena; Mckenzie Christopher; Chaponnier Christine; Grau Georges E.; Newsome Timothy P.;
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作者单位

School of Life and Environmental SciencesThe University of SydneyAustralia;

Vascular Immunology Unit Department of PathologySchool of Medical Sciences &

Marie Bashir;

School of Life and Environmental SciencesThe University of SydneyAustralia;

School of Life and Environmental SciencesThe University of SydneyAustralia;

Department of Pathology‐Immunology Faculty of MedicineUniversity of GenevaSwitzerland;

Vascular Immunology Unit Department of PathologySchool of Medical Sciences &

Marie Bashir;

School of Life and Environmental SciencesThe University of SydneyAustralia;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
actin; transport; virus;

机译：actin;运输;病毒;

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机译：β-和γ-肌动蛋白同种型在痘苗病病毒传播期间发散的作用
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Divergent roles of β‐ and γ‐actin isoforms during spread of vaccinia virus

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