Altered Antibody Responses in Persons Infected with HIV-1 While Using Preexposure Prophylaxis

Parker Ivana; Khalil George; Martin Amy; Martin Michael; Vanichseni Suphak; Leelawiwat Wanna; McNicholl Janet; Hickey Andrew; Garcia-Lerma J. Gerardo; Choopanya Kachit; Curtis Kelly A.

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Altered Antibody Responses in Persons Infected with HIV-1 While Using Preexposure Prophylaxis

机译：在使用预防预防的同时感染HIV-1的人的改变抗体反应

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Preexposure prophylaxis (PrEP) is an effective HIV prevention tool, although effectiveness is dependent upon adherence. It is important to characterize the impact of PrEP on HIV antibody responses in people who experience breakthrough infections to understand the potential impact on timely diagnosis and treatment. Longitudinal HIV-1-specific antibody responses were evaluated in 42 people who inject drugs (PWID) from the Bangkok Tenofovir Study (BTS) (placebo = 28; PrEP = 14) who acquired HIV while receiving PrEP. HIV-1 antibody levels and avidity to three envelope proteins (gp41, gp160, and gp120) were measured in the plasma using a customized Bio-Plex (Bio-Rad Laboratories, Hercules, CA) assay. A time-to-event analysis was performed for each biomarker to compare the distribution of times at which study subjects exceeded the recent/long-term assay threshold, comparing PrEP and placebo treatment groups. We fit mixed-effects models to identify longitudinal differences in antibody levels and avidity between groups. Overall, longitudinal antibody levels and avidity were notably lower in the PrEP breakthrough group compared to the placebo group. Time-to-event analyses demonstrated a difference in time to antibody reactivity between treatment groups for all Bio-Plex biomarkers. Longitudinal gp120 antibody levels within the PrEP breakthrough group were decreased compared to the placebo group. When accounting for PrEP adherence, both gp120 and gp160 antibody levels were lower in the PrEP breakthrough group compared to the placebo group. We demonstrate hindered envelope antibody maturation in PWID who became infected while receiving PrEP in the BTS, which has significant implications for HIV diagnosis. Delayed maturation of the antibody response to HIV may increase the time to detection for antibody-based tests.

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来源
《AIDS Research and Human Retroviruses》 |2021年第3期|共7页
作者
Parker Ivana; Khalil George; Martin Amy; Martin Michael; Vanichseni Suphak; Leelawiwat Wanna; McNicholl Janet; Hickey Andrew; Garcia-Lerma J. Gerardo; Choopanya Kachit; Curtis Kelly A.;
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作者单位

Ctr Dis Control &

Prevent Natl Ctr HIV AIDS Hepatitis STD &

TB Prevent Div HIV AIDS Prevent;

Ctr Dis Control &

Prevent Natl Ctr HIV AIDS Hepatitis STD &

TB Prevent Div HIV AIDS Prevent;

Ctr Dis Control &

Prevent Natl Ctr HIV AIDS Hepatitis STD &

TB Prevent Div HIV AIDS Prevent;

Ctr Dis Control &

Prevent Natl Ctr HIV AIDS Hepatitis STD &

TB Prevent Div HIV AIDS Prevent;

US Ctr Dis Control &

Prevent Collaborat Thailand Minist Publ Hlth Nonthaburi Thailand;

Ctr Dis Control &

Prevent Natl Ctr HIV AIDS Hepatitis STD &

TB Prevent Div HIV AIDS Prevent;

Ctr Dis Control &

Prevent Natl Ctr HIV AIDS Hepatitis STD &

TB Prevent Div HIV AIDS Prevent;

Ctr Dis Control &

Prevent Natl Ctr HIV AIDS Hepatitis STD &

TB Prevent Div HIV AIDS Prevent;

Ctr Dis Control &

Prevent Natl Ctr HIV AIDS Hepatitis STD &

TB Prevent Div HIV AIDS Prevent;

Bangkok Metropolitan Assoc Bangkok Thailand;

Ctr Dis Control &

Prevent Natl Ctr HIV AIDS Hepatitis STD &

TB Prevent Div HIV AIDS Prevent;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
antibody maturation; preexposure prophylaxis; HIV; seroconversion;

机译：抗体成熟;预防预防;艾滋病毒;Seroconversion;

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机译：艾滋病毒/艾滋病监测补充报告。第9卷，第3号。艾滋病毒感染者获得和使用治疗和预防的选定措施

Altered Antibody Responses in Persons Infected with HIV-1 While Using Preexposure Prophylaxis

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