HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences

Mikasi Sello Given; Isaacs Darren; Ikomey George Mondinde; Shimba Henerico; Cloete Ruben; Jacobs Graeme Brendon

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HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences

机译：喀麦隆衍生的整合酶序列的HIV-1耐药性突变分析

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HIV-1 integrase (IN) is a primary target for combination antiretroviral therapy. Only a limited number of studies report on the emergence of resistance-associated mutations (RAMs) in Cameroon. We observed that 1.4% of sequence from treatment-naive patients had IN strand transfer inhibitor (INSTI) RAMs. These mutations confer resistance to raltegravir and elvitegravir. We also observed that 10.1% of the sequences have INSTI accessory RAMs. HIV-1 CRF02_AG was the predominant subtype (44.7%) in this study analyses. The occurrence of INSTI RAMs among the sequences at baseline needs to be monitored carefully.

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来源
《AIDS Research and Human Retroviruses》 |2021年第1期|共3页
作者
Mikasi Sello Given; Isaacs Darren; Ikomey George Mondinde; Shimba Henerico; Cloete Ruben; Jacobs Graeme Brendon;
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作者单位

Stellenbosch Univ Fac Med &

Hlth Sci Dept Pathol Div Med Virol ZA-7505 Cape Town South Africa;

Univ Western Cape South African Natl Bioinformat Inst South African Med Res Council Bioinformat;

Univ Yaounde I Fac Med &

Biomed Sci Ctr Study &

Control Communicable Dis Yaounde Cameroon;

Stellenbosch Univ Fac Med &

Hlth Sci Dept Pathol Div Med Virol ZA-7505 Cape Town South Africa;

Univ Yaounde I Fac Med &

Biomed Sci Ctr Study &

Control Communicable Dis Yaounde Cameroon;

Stellenbosch Univ Fac Med &

Hlth Sci Dept Pathol Div Med Virol ZA-7505 Cape Town South Africa;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
HIV-1; integrase; resistance; Cameroon; diversity; CRF02_AG;

机译：HIV-1;整合酶;抵抗;喀麦隆;多样性;CRF02_AG;

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2. Allele-specific real-time PCR testing for minor HIV-1 drug resistance mutations: assay preparation and application to reveal dynamic of mutations in vivo [J] . GUO Dong-xing, LI Jing-yun, LI Han-ping, 中华医学杂志（英文版） . 2010,第023期
3. Drug Resistance to HIV-1 Integrase Inhibitors among Treatment-naive Patients in Jiangsu, China [J] . YIN Yue Qi, XU Xiao Qin, FU Geng Feng, 生物医学与环境科学（英文版） . 2021,第005期
4. First Report of Drug Resistance against HIV-1 Integrase Inhibitors in Iran [J] . Mohammad GHOLAMI, Negin Hosseini ROUZBAHANI, Leila TAJ, 国际转化医学杂志（英文版） . 2019,第001期
5. HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon [J] . AIDS Research and Human Retroviruses . 2020,第5期

机译：来自喀麦隆的整体酶链转移抑制剂 - Naivive HIV-1患者中的HIV-1整合酶多样性和抗性相关突变和多态性
6. Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor. [J] . Goethals O, Van Ginderen M, Vos A, Antiviral Research . 2011,第2期

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7. Secondary integrase resistance mutations found in HIV-1 minority quasispecies in integrase therapy-naive patients have little or no effect on susceptibility to integrase inhibitors. [J] . Ceccherini Silberstein F, Van Baelen K, Armenia D, Antimicrobial agents and chemotherapy. . 2010,第9期

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8. Computational Mutation Scanning and Drug Resistance Mechanisms of HIV-1 Protease Inhibitors [C] . Ge-Fei Hao, Guang-Fu Yang, Chang-Guo Zhan ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

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机译：在Tokai地区HIV-1中新诊断患有HIV-1整合酶多态性和耐药性突变的患病率
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HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences

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