Chronic binge alcohol consumption during pregnancy alters rat maternal uterine artery pressure response

Naik Vishal D.; Lunde-Young Emilie R.; Davis-Anderson Katie L.; Orzabal Marcus; Ivanov Ivan; Ramadoss Jayanth

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Chronic binge alcohol consumption during pregnancy alters rat maternal uterine artery pressure response

机译：妊娠期间的慢性泪液消耗改变了大鼠母体子宫动脉压力反应

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We aimed to investigate pressure-dependent maternal uterine artery responses and vessel remodeling following gestational binge alcohol exposure. Two groups of pregnant rats were used: the alcohol group (28.5% wt/v, 6.0 g/kg, once-daily orogastric gavage in a binge paradigm between gestational day (GD) 5-19) and pair-fed controls (isocalorically matched). On GD20, excised, pressurized primary uterine arteries were studied following equilibration (60 mm Hg) using dual chamber arteriograph. The uterine artery diameter stabilized at 20 mm Hg, showed passive distension at 40 mm Hg, and redeveloped tone at 60 mm Hg. An alcohol effect (P = 0.0025) was observed on the percent constriction of vessel diameter with greater pressure-dependent myogenic constriction. Similar alcohol effect was noted with lumen diameter response (P = 0.0020). The percent change in media:lumen ratio was higher in the alcohol group (P < 0.0001). Thus, gestational alcohol affects pressure-induced uterine artery reactivity, inward-hypotrophic remodeling, and adaptations critical for nutrient delivery to the fetus. (C) 2016 Elsevier Inc. All rights reserved.

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来源
《Alcohol》 |2016年第2016期|共6页
作者
Naik Vishal D.; Lunde-Young Emilie R.; Davis-Anderson Katie L.; Orzabal Marcus; Ivanov Ivan; Ramadoss Jayanth;
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作者单位

Texas A&

M Univ Dept Vet Physiol &

Pharmacol Coll Vet Med &

Biomed Sci College Stn TX 77843 USA;

Texas A&

M Univ Dept Vet Physiol &

Pharmacol Coll Vet Med &

Biomed Sci College Stn TX 77843 USA;

Texas A&

M Univ Dept Vet Physiol &

Pharmacol Coll Vet Med &

Biomed Sci College Stn TX 77843 USA;

Texas A&

M Univ Dept Vet Physiol &

Pharmacol Coll Vet Med &

Biomed Sci College Stn TX 77843 USA;

Texas A&

M Univ Dept Vet Physiol &

Pharmacol Coll Vet Med &

Biomed Sci College Stn TX 77843 USA;

Texas A&

M Univ Dept Vet Physiol &

Pharmacol Coll Vet Med &

Biomed Sci College Stn TX 77843 USA;

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原文格式 PDF
正文语种 eng
中图分类中毒及化学性损害;
关键词
FASD; Pregnancy; Uterine; Alcohol;

机译：FasD;怀孕;子宫;酒精;

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5. Chronic binge alcohol consumption during pregnancy alters rat maternal uterine artery pressure response [J] . Naik Vishal D., Lunde-Young Emilie R., Davis-Anderson Katie L., Alcohol . 2016,第期

机译：妊娠期间的慢性泪液消耗改变了大鼠母体子宫动脉压力反应
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Chronic binge alcohol consumption during pregnancy alters rat maternal uterine artery pressure response

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