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Modeling the conversion between specific IgE test platforms for nut allergens in children and adolescents

机译：在儿童和青少年螺母过敏原的特定IgE试验平台转换

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摘要

Background Multiplex tests allow for measurement of allergen-specific IgE responses to multiple extracts and molecular allergens and have several advantages for large cohort studies. Due to significant methodological differences, test systems are difficult to integrate in meta-analyses/systematic reviews since there is a lack of datasets with direct comparison. We aimed to create models for statistical integration of allergen-specific IgE to peanut/tree nut allergens from three IgE test platforms. Methods Plasma from Canadian and Austrian children/adolescents with peanut/tree nut sensitization and a cohort of sensitized, high-risk, pre-school asthmatics (total n = 166) were measured with three R&D multiplex IgE test platforms: Allergy Explorer version 1 (ALEX) (Macro Array Dx), MeDALL-chip (Mechanisms of Development of Allergy) (Thermo Fisher), and EUROLINE (EUROIMMUN). Skin prick test (n = 51) and ImmunoCAP (Thermo Fisher) (n = 62) results for extracts were available in a subset. Regression models (Multivariate Adaptive Regression Splines, local polynomial regression) were applied if >30% of samples were positive to the allergen. Intra-test correlations between PR-10 and nsLTP allergens were assessed. Results Using two regression methods, we demonstrated the ability to model allergen-specific relationships with acceptable measures of fit (r(2) = 94%-56%) for peanut and tree nut sIgE testing at the extract and molecular-level, in order from highest to lowest: Ara h 2, Ara h 6, Jug r 1, Ana o 3, Ara h 1, Jug r 2, and Cor a 9. Conclusion Our models support the notion that quantitative conversion is possible between sIgE multiplex platforms for extracts and molecular allergens and may provide options to aggregate data for future meta-analysis.
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  • 来源
    《Allergy》 |2021年第3期|共11页
  • 作者

    Hoang Jennifer A.; Celik Alper; Lupinek Christian; Valenta Rudolf; Duan Lucy; Dai Ruixue; Brydges May G.; Dubeau Aimee; Lepine Claire; Wong Samantha; Alexanian-Farr Mara; Magder Ahuva; Subbarao Padmaja; Upton Julia E. M.; Schmidthaler Klara; Szepfalusi Zsolt; Ramani Arun; Eiwegger Thomas;

  • 作者单位

    Hosp Sick Children Res Inst Translat Med Program Toronto ON Canada;

    Hosp Sick Children Ctr Computat Med Toronto ON Canada;

    Med Univ Vienna Ctr Pathophysiol Infectiol &

    Immunol Dept Pathophysiol &

    Allergy Res Div;

    Med Univ Vienna Ctr Pathophysiol Infectiol &

    Immunol Dept Pathophysiol &

    Allergy Res Div;

    Hosp Sick Children Dept Pediat Div Immunol &

    Allergy Food Allergy &

    Anaphylaxis Program 555;

    Hosp Sick Children Res Inst Translat Med Program Toronto ON Canada;

    Hosp Sick Children Res Inst Translat Med Program Toronto ON Canada;

    Hosp Sick Children Res Inst Translat Med Program Toronto ON Canada;

    Hosp Sick Children Res Inst Translat Med Program Toronto ON Canada;

    Hosp Sick Children Dept Pediat Div Immunol &

    Allergy Food Allergy &

    Anaphylaxis Program 555;

    Hosp Sick Children Dept Pediat Div Immunol &

    Allergy Food Allergy &

    Anaphylaxis Program 555;

    Hosp Sick Children Dept Pediat Div Immunol &

    Allergy Food Allergy &

    Anaphylaxis Program 555;

    Hosp Sick Children Res Inst Translat Med Program Toronto ON Canada;

    Hosp Sick Children Dept Pediat Div Immunol &

    Allergy Food Allergy &

    Anaphylaxis Program 555;

    Med Univ Vienna Dept Pediat &

    Adolescent Med Div Pediat Pulmonol Allergol &

    Endocrinol Vienna;

    Med Univ Vienna Dept Pediat &

    Adolescent Med Div Pediat Pulmonol Allergol &

    Endocrinol Vienna;

    Hosp Sick Children Ctr Computat Med Toronto ON Canada;

    Hosp Sick Children Res Inst Translat Med Program Toronto ON Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergen; conversion; food allergy; molecular allergology; specific IgE;

    机译：过敏原;转化;食物过敏;分子过敏症;特定的IgE;

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