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Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization

机译：茅场随机化估算体重指数对花粉，哮喘和肺功能的因果效应

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摘要

Abstract Background Observational studies have shown that body mass index ( BMI ) is positively associated with asthma. However, observational data are prone to confounding and reverse causation. In Mendelian randomization, genetic variants are used as unconfounded markers of exposures to examine causal effects. We examined the causal effect of BMI on asthma, hay fever, allergic sensitization, serum total immunoglobulin E (IgE), forced expiratory volume in one‐second ( FEV 1) and forced vital capacity ( FVC ). Methods We included 490?497 participants in the observational and 162?124 participants in the genetic analyses. A genetic risk score ( GRS ) was created using 26 BMI ‐associated single nucleotide polymorphisms ( SNP s). Results were pooled in meta‐analyses and expressed as odds ratios ( OR s) or β‐estimates with 95% confidence interval ( CI ). Results The GRS was significantly associated with asthma ( OR =1.009; 95% CI : 1.004, 1.013), but not with hay fever ( OR = 0.998; 95% CI : 0.994, 1.002) or allergic sensitization ( OR =0.999; 95% CI : 0.986, 1.012) per BMI ‐increasing allele. The GRS was significantly associated with decrease in FEV 1: β=?0.0012 (95% CI : ?0.0019, ?0.0006) and FVC : β=?0.0022 (95% CI : ?0.0031, ?0.0014) per BMI ‐increasing allele. Effect sizes estimated by instrumental variable analyses were OR =1.07 (95% CI : 1.03, 1.10) for asthma, a 9 ml decrease in FEV 1 (95% CI : 2.0‐15?mL decrease) and a 16 ml decrease in FVC (95% CI : 7.0‐24?mL decrease) per 1?kg/m 2 higher BMI . Conclusions The results support the conclusion that increasing BMI is causally related to higher prevalence of asthma and decreased lung function, but not with hay fever or biomarkers of allergy.
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  • 来源
    《Allergy》 |2018年第1期|共12页
  • 作者

    Skaaby T.; Taylor A. E.; Thuesen B. H.; Jacobsen R. K.; Friedrich N.; M?llehave L. T.; Hansen S.; Larsen S. C.; V?lker U.; Nauck M.; V?lzke H.; Hansen T.; Pedersen O.; J?rgensen T.; Paternoster L.; Munafò M.; Grarup N.; Linneberg A.;

  • 作者单位

    Research Centre for Prevention and HealthCapital Region of DenmarkCopenhagen Denmark;

    MRC Integrative Epidemiology Unit (IEU)Bristol UK;

    Research Centre for Prevention and HealthCapital Region of DenmarkCopenhagen Denmark;

    Research Centre for Prevention and HealthCapital Region of DenmarkCopenhagen Denmark;

    Research Centre for Prevention and HealthCapital Region of DenmarkCopenhagen Denmark;

    Research Centre for Prevention and HealthCapital Region of DenmarkCopenhagen Denmark;

    Research Centre for Prevention and HealthCapital Region of DenmarkCopenhagen Denmark;

    Research unit for Dietary StudiesThe Capital RegionFrederiksberg Denmark;

    Interfaculty Institute for Genetics and Functional GenomicsUniversity Medicine and Ernst‐Moritz;

    Institute of Clinical Chemistry and Laboratory MedicineUniversity Medicine GreifswaldGreifswald;

    Institute for Community MedicineUniversity Medicine GreifswaldGreifswald Germany;

    Section?on Metabolic GeneticsUniversity of CopenhagenCopenhagen Denmark;

    Section?on Metabolic GeneticsUniversity of CopenhagenCopenhagen Denmark;

    Research Centre for Prevention and HealthCapital Region of DenmarkCopenhagen Denmark;

    MRC Integrative Epidemiology Unit (IEU)Bristol UK;

    MRC Integrative Epidemiology Unit (IEU)Bristol UK;

    Section?on Metabolic GeneticsUniversity of CopenhagenCopenhagen Denmark;

    Research Centre for Prevention and HealthCapital Region of DenmarkCopenhagen Denmark;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergic disease; allergic sensitization; asthma; hay fever; serum‐specific IgE;

    机译：过敏性疾病;过敏性敏化;哮喘;花粉发烧;血清特异性IgE;

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