Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation

Scholz Josephine; Kuhrau Julia; Heinrich Frederik; Heinz Gitta Anne; Hutloff Andreas; Worm Margitta; Heine Guido

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Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation

机译：维生素A通过T滤泡辅助细胞以及Plasmablast分化控制过敏反应

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Background Vitamin A regulates the adaptive immune response and a modulatory impact on type I allergy is discussed. The cellular mechanisms are largely unknown. Objective To determine the vitamin A-responding specific lymphocyte reaction in vivo. Methods Antigen-specific B and T lymphocytes were analyzed in an adoptive transfer airway inflammation mouse model in response to 9-cis retinoic acid (9cRA) and after lymphocyte-specific genetic targeting of the receptor RAR alpha. Flow cytometry, quantitative PCR, next-generation sequencing, and specific Ig-ELISA were used to characterize the cells functionally. Results Systemic 9cRA profoundly enhanced the specific IgA-secreting B-cell frequencies in the lung tissue and serum IgA while reducing serum IgE concentrations. RAR alpha overexpression in antigen-specific B cells promoted differentiation into plasmablasts at the expense of germinal center B cells. In antigen-specific T cells, RAR alpha strongly promoted the differentiation of T follicular helper cells followed by an enhanced germinal center response. Conclusions 9cRA signaling via RAR alpha impacts the allergen-specific immunoglobulin response directly by the differentiation of B cells and indirectly by promoting T follicular helper cells.

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来源
《Allergy》 |2021年第4期|共14页
作者
Scholz Josephine; Kuhrau Julia; Heinrich Frederik; Heinz Gitta Anne; Hutloff Andreas; Worm Margitta; Heine Guido;
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作者单位

Humboldt Univ Charite Univ Berlin Berlin Inst Hlth Div Allergy &

Immunol Dept Dermatol Venereol;

Leibniz Inst Deutsch Rheuma Forschungszentrum A Berlin Germany;

Leibniz Inst Deutsch Rheuma Forschungszentrum A Berlin Germany;

Leibniz Inst Deutsch Rheuma Forschungszentrum A Berlin Germany;

Leibniz Inst Deutsch Rheuma Forschungszentrum A Berlin Germany;

Humboldt Univ Charite Univ Berlin Berlin Inst Hlth Div Allergy &

Immunol Dept Dermatol Venereol;

Humboldt Univ Charite Univ Berlin Berlin Inst Hlth Div Allergy &

Immunol Dept Dermatol Venereol;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
9-cis retinoic acid; allergy; RAR; Tfh cells; vitamin A;

机译：9-CIS维甲酸;过敏;RAR;TFH细胞;维生素A;

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1. The role of the T follicular helper cells in allergic disease [J] . DM Kemeny 中国免疫学杂志（英文版） . 2012,第005期
2. The role of the T follicular helper cells in allergic disease [J] . DM Kemeny 细胞与分子免疫学：英文版 . 2012,第005期
3. IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome [J] . Xiang Lin, Xiaohui Wang, Fan Xiao, 细胞与分子免疫学：英文版 . 2019,第012期
4. The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection [J] . Xiangyu Chen, Guoshuai Cao, Jialin Wu, 细胞与分子免疫学：英文版 . 2020,第003期
5. An optimized method to differentiate mouse follicular helper T cells in vitro [J] . Xin Gao, Hao Wang, Zhian Chen, 细胞与分子免疫学：英文版 . 2020,第007期
6. Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib [J] . Laure Ricard, Vincent Jachiet, Florent Malard, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2019,第4期

机译：循环滤泡辅助T细胞在全身硬化症中增加，并通过IL-21途径促进血浆曲线分化，该途径可以被Ruxolitinib抑制
7. Cutting Edge: Circulating Plasmablasts Induce the Differentiation of Human T Follicular Helper Cells via IL-6 Production [J] . Konstantia-Maria Chavele, Eve Merry, Michael R. Ehrenstein The journal of immunology . 2015,第6期

机译：尖端：循环浆细胞通过IL-6产生诱导人T卵泡辅助细胞的分化
8. Cutting Edge: Circulating Plasmablasts Induce the Differentiation of Human T Follicular Helper Cells via IL-6 Production [J] . Chavele Konstantia-Maria, Merry Eve, Ehrenstein Michael R. The Journal of Immunology: Official Journal of the American Association of Immunologists . 2015,第6期

机译：尖端：循环浆细胞通过IL-6产生诱导人类T卵泡辅助细胞的分化
9. Integrating Control of Mast Cell Function and Allergic Responses [C] . J. Rivera, T. Baumruker, M.A. Beaven, Collegium Internationale Allergologicum . 2007

机译：整合肥大细胞功能和过敏反应的控制
10. T Follicular Regulatory Cells Promote the Germinal Center Reaction and Allergic IgE Response While Repressing Abnormal Differentiation of T Follicular Helper Cells [D] . Xie, Ming. 2019

机译：T卵泡调节细胞促进生发中心反应和过敏性IgE反应，同时抑制T卵泡辅助细胞的异常分化
11. Plasmablast Memory B Cell CD4+ T Cell and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine [O] . Evan J. Anderson, Lilin Lai, Jens Wrammert, 2020

机译：血浆母细胞记忆B细胞CD4 + T细胞和循环性滤泡辅助T细胞对非复制型修饰痘苗安卡拉疫苗的反应
12. Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation [O] . Josephine Scholz, Julia Kuhrau, Frederik Heinrich, 2020

机译：维生素A通过T卵泡辅助细胞以及Plasmablast分化控制过敏反应
13. Role of Lecithin: Retinol Acyltransferase (LRAT)-Mediated Esterification of Vitamin A in Regulating Human Breast Cancer Cell Proliferation and Differentiation [R] . Su, D. , Gudas, L. J. 2007

机译：卵磷脂的作用：视黄醇酰基转移酶（LRaT）介导的维生素a酯化调节人乳腺癌细胞的增殖和分化

Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation

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