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首页> 外文期刊>Allergy >Tape strips from early-onset pediatric atopic dermatitis highlight disease abnormalities in nonlesional skin
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Tape strips from early-onset pediatric atopic dermatitis highlight disease abnormalities in nonlesional skin

机译：从早期出现的儿科特应性皮炎的胶带剥离了无源性皮肤的疾病异常

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摘要

Background Skin biopsies promote our understanding of atopic dermatitis/AD pathomechanisms in infants/toddlers with early-onset AD, but are not feasible in pediatric populations. Tape strips are an emerging, minimally invasive alternative, but global transcriptomic profiling in early pediatric AD is lacking. We aimed to provide global lesional and nonlesional skin profiles of infants/toddlers with recent-onset, moderate-to-severe AD using tape strips. Methods Sixteen tape strips were collected for RNA-seq profiling from 19 infants/toddlers ( = 2, FDR <0.05), with 100% sample recovery. Both lesional and nonlesional skin showed significant dysregulations of Th2 (CCL17 and IL4R) and Th22/Th17 (IL36G, CCL20, and S100As)-related genes, largely lacking significant Th1-skewing. Significant down-regulation of terminal differentiation (FLG and FLG2), lipid synthesis/metabolism (ELOVL3 and FA2H), and tight junction (CLDN8) genes were primarily seen in lesional AD. Significant negative correlations were identified between Th2 measures and epidermal barrier gene-subsets and individual genes (FLG with IL-4R and CCL17;r < -0.4,P < .05). Significant correlations were also identified between clinical measures (body surface area/BSA, pruritus ADQ, and transepidermal water loss/TEWL) with immune and barrier mRNAs in lesional and/or nonlesional AD (FLG/FLG2 with TEWL;r < -0.4,P < .05). Conclusion RNA-seq profiling using tape strips in early-onset pediatric AD captures immune and barrier alterations in both lesional and nonlesional skin. Tape strips provide insight into disease pathomechanisms and cutaneous disease activity.
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  • 来源
    《Allergy》 |2021年第1期|共12页
  • 作者

    Pavel Ana B.; Renert-Yuval Yael; Wu Jianni; Del Duca Ester; Diaz Aisleen; Lefferdink Rachel; Fang Milie M.; Canter Talia; Rangel Stephanie M.; Zhang Ning; Krueger James G.; Paller Amy S.; Guttman-Yassky Emma;

  • 作者单位

    Icahn Sch Med Mt Sinai Lab Inflammatory Skin Dis Dept Dermatol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Lab Inflammatory Skin Dis Dept Dermatol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Lab Inflammatory Skin Dis Dept Dermatol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Lab Inflammatory Skin Dis Dept Dermatol New York NY 10029 USA;

    Rockefeller Univ Lab Investigative Dermatol 1230 York Ave New York NY 10021 USA;

    Northwestern Univ Feinberg Sch Med Dept Dermatol Chicago IL 60611 USA;

    Northwestern Univ Feinberg Sch Med Dept Dermatol Chicago IL 60611 USA;

    Northwestern Univ Feinberg Sch Med Dept Dermatol Chicago IL 60611 USA;

    Ponce Hlth Sci Univ Sch Med Ponce PR USA;

    Icahn Sch Med Mt Sinai Lab Inflammatory Skin Dis Dept Dermatol New York NY 10029 USA;

    Rockefeller Univ Lab Investigative Dermatol 1230 York Ave New York NY 10021 USA;

    Northwestern Univ Feinberg Sch Med Dept Dermatol Chicago IL 60611 USA;

    Icahn Sch Med Mt Sinai Lab Inflammatory Skin Dis Dept Dermatol New York NY 10029 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    atopic dermatitis; biomarker; pediatric; skin barrier; tape strips;

    机译：特应性皮炎;生物标志物;小儿;皮肤屏障;胶带;

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