The H4R is highly expressed on eosinophils from AD patients and IL-4 upregulates expression and function via the JAK/STAT pathway

Schaper-Gerhardt Katrin; Koether Brigitta; Wolff Luca; Kabatas Aylin; Gehring Manuela; Nikolouli Eirini; Mommert Susanne; Werfel Thomas; Gutzmer Ralf

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The H4R is highly expressed on eosinophils from AD patients and IL-4 upregulates expression and function via the JAK/STAT pathway

机译：H4R在来自AD患者的嗜酸性粒细胞上高度表达，IL-4通过JAK / Stat途径上调表达和功能

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来源
《Allergy》 |2021年第4期|共4页
作者
Schaper-Gerhardt Katrin; Koether Brigitta; Wolff Luca; Kabatas Aylin; Gehring Manuela; Nikolouli Eirini; Mommert Susanne; Werfel Thomas; Gutzmer Ralf;
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作者单位

Hannover Med Sch Dept Dermatol &

Allergy Div Immunodermatol &

Allergy Res Hannover Germany;

Hannover Med Sch Dept Dermatol &

Allergy Div Immunodermatol &

Allergy Res Hannover Germany;

Hannover Med Sch Dept Dermatol &

Allergy Div Immunodermatol &

Allergy Res Hannover Germany;

Hannover Med Sch Dept Dermatol &

Allergy Div Immunodermatol &

Allergy Res Hannover Germany;

Hannover Med Sch Dept Dermatol &

Allergy Div Immunodermatol &

Allergy Res Hannover Germany;

Hannover Med Sch Dept Dermatol &

Allergy Div Immunodermatol &

Allergy Res Hannover Germany;

Hannover Med Sch Dept Dermatol &

Allergy Div Immunodermatol &

Allergy Res Hannover Germany;

Hannover Med Sch Dept Dermatol &

Allergy Div Immunodermatol &

Allergy Res Hannover Germany;

Hannover Med Sch Dept Dermatol &

Allergy Div Immunodermatol &

Allergy Res Hannover Germany;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
atopic dermatitis; eosinophils; H4R; histamine; IL-31;

机译：特应性皮炎;嗜酸性粒细胞;H4R;组胺;IL-31;

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2. JAK2-STAT3 pathway regulates the expression of complement factor B in autosomal dominant polycystic kidney disease [J] . 周晨晨中国医学文摘：内科学分册（英文版） . 2014,第002期
3. Detection of serum tumor marker contents of liver cancer patients and itscorrelation with JAK-STAT pathway in tumor tissue [J] . Zhi-Gang Dong, Li-Li Ma, Ya-Juan Li, 海南医科大学学报（英文版） . 2015,第009期
4. Detection of serum CD44v6, HMGB1, GP73 contents of liver cancer patients and its correlation with JAK-STAT pathway in tumor tissue [J] . Ying-Xiang Yin 海南医科大学学报（英文版） . 2015,第009期
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机译：人和啮齿动物的胰腺β细胞表达IL-4受体，IL-4通过激活PI3K和JAK / STAT通路来保护β细胞免于凋亡
6. Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. [J] . Kaminski A., Welters H.J., Kaminski E.R., Bioscience Reports . 2010,第3期

机译：人和啮齿动物的胰腺β细胞表达IL-4受体，而IL-4通过激活PI3K和JAK / STAT通路来防止β细胞凋亡。
7. Ras/Erk pathway positively regulates Jak1/STAT6 activity and IL-4 gene expression in Jurkat T cells. [J] . So EY, Oh J, Jang JY, Molecular Immunology . 2007,第13期

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8. α-S1-casein (CSN1S1) suppresses β-casein expression via JAK2/STAT5a signaling pathway in goat mammary epithelial cells [C] . Ning Song, Jun Luo, Yating Chen The 6th International Symposium on Dairy Cow Nutrition and Milk Quality（第六届“奶牛营养与牛奶质量”国际研讨会）论文集 . -1

机译：α-S1-酪蛋白（CSN1S1）通过JAK2 / Stat5a信号传导途径在山羊乳状上皮细胞中抑制β-酪蛋白表达
9. The role of the JAK/STAT signal transduction pathway in the biology of the human eosinophil. [D] . Stout, Barbara Anne. 2003

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10. Regulation of Skin Barrier Function via Competition between AHR Axis versus IL-13/IL-4‒JAK‒STAT6/STAT3 Axis: Pathogenic and Therapeutic Implications in Atopic Dermatitis [O] . Masutaka Furue 2020

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11. Human and rodent pancreatic β-cells express IL-4 receptors and IL-4 protects against β-cell apoptosis by activation of the PI-3-Kinase and Jak/STAT pathways [O] . Kaminski Anna, Welters Hannah J, Kaminski Edward R, 2009

机译：人和啮齿动物的胰腺β细胞表达IL-4受体，IL-4通过激活PI-3-激酶和Jak / STAT通路来保护β细胞免于凋亡
12. Role of the Interferon-Gamma-Jak/STAT Pathway in Rheumatoid Arthritis. [R] . Bridges, S. J. L. 2017

机译：干扰素-Gamma-Jak / sTaT途径在类风湿性关节炎中的作用。

The H4R is highly expressed on eosinophils from AD patients and IL-4 upregulates expression and function via the JAK/STAT pathway

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