Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors

Radzikowska Urszula; Ding Mei; Tan Ge; Zhakparov Damir; Peng Yaqi; Wawrzyniak Paulina; Wang Ming; Li Shuo; Morita Hideaki; Altunbulakli Can; Reiger Matthias; Neumann Avidan U.; Lunjani Nonhlanhla; Traidl-Hoffmann Claudia; Nadeau Kari C.; OMahony Liam; Akdis Cezmi; Sokolowska Milena

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Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors

机译：ACE2，CD147，CD26和其他SARS-COV-2在健康中的组织和免疫细胞中的相关分子和哮喘，COPD，肥胖，高血压和Covid-19风险因素的分布

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Background Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, and novel clinical presentations of COVID-19 are often reported. The range of human cells and tissues targeted by SARS-CoV-2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS-CoV-2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID-19. Methods We performed RNA sequencing and explored available RNA-Seq databases to study gene expression and co-expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4(+)and CD8(+)T cells, B cells, and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID-19 risk factor status. Results ACE2andTMPRSS2were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIAandPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age-related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2- and CD147-related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147-related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147-related genes in the lesional skin of patients with atopic dermatitis. Conclusions Our data suggest different receptor repertoire potentially involved in the SARS-CoV-2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID-19 morbidity and severity patterns.

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来源
《Allergy》 |2020年第11期|共17页
作者
Radzikowska Urszula; Ding Mei; Tan Ge; Zhakparov Damir; Peng Yaqi; Wawrzyniak Paulina; Wang Ming; Li Shuo; Morita Hideaki; Altunbulakli Can; Reiger Matthias; Neumann Avidan U.; Lunjani Nonhlanhla; Traidl-Hoffmann Claudia; Nadeau Kari C.; OMahony Liam; Akdis Cezmi; Sokolowska Milena;
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作者单位

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Tech Univ Munich Chair &

Inst Environm Med UNIKA T Augsburg Germany;

Tech Univ Munich Chair &

Inst Environm Med UNIKA T Augsburg Germany;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Christine Kuhne Ctr Res &

Educ CK CARE Davos Switzerland;

Stanford Univ Dept Med Sch Med Sean N Parker Ctr Allergy &

Asthma Res Stanford CA 94305 USA;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
asthma; COPD; COVID-19; COVID-19 children; hypertension; obesity; SARS receptor;

机译：哮喘;COPD;Covid-19;Covid-19儿童;高血压;肥胖;SARS受体;

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1. Repurposing FDA-approved drugs to fight COVID-19 using in silico methods: Targeting SARS-CoV-2 RdRp enzyme and host cell receptors (ACE2, CD147) through virtual screening and molecular dynamic simulations [J] . Soodeh Mahdian, Mahboobeh Zarrabi, Yunes Panahi, Informatics in Medicine Unlocked . 2021,第a期

机译：通过在硅中释放FDA批准的药物来对抗Covid-19，在Silico 方法：通过虚拟筛选和分子动态模拟靶向SARS-COV-2 RDRP酶和宿主细胞受体（ACE2，CD147）
2. ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19 [J] . Riyue Bao, Kyle Hernandez, Lei Huang, Journal for ImmunoTherapy of Cancer . 2020,第2期

机译：临床，HLA，免疫和微生物的ACE2和TMPRSS2表达跨越34人癌症和匹配的正常组织：对SARS-COV-2 Covid-19的影响
3. Presence of sarcopenia in asthma–COPD overlap syndrome may be a risk factor for decreased bone-mineral density, unlike asthma: Korean National Health and Nutrition Examination Survey (KNHANES) IV and V (2008–2011) [J] . Dong-Won Lee, Hyun-Jung Jin, Kyeong-Cheol Shin, International Journal of Chronic Obstructive Pulmonary Disease . 2017,第1期

机译：与哮喘不同，哮喘中少肌症的存在-COPD重叠综合征可能是导致骨矿物质密度降低的危险因素：韩国国家健康与营养检查问卷（KNHANES）IV和V（2008-2011）
4. Original research: ACE2 and TMPRSS2 expression by clinical HLA immune and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19 [O] . Riyue Bao, Kyle Hernandez, Lei Huang, -1

机译：原始研究：临床HLA免疫和微生物中的ACE2和TMPRSS2表达在34种人类癌症和匹配的正常组织中相关：对SARS-CoV-2 COVID-19的影响
5. Distribution of ACE2, CD147, CD26, and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors [O] . Urszula Radzikowska, Mei Ding, Ge Tan, 2020

机译：ACE2，CD147，CD26和其他SARS-COV-2在健康和免疫细胞中的SARS-COV-2相关分子在健康和哮喘，COPD，肥胖，高血压和Covid-19风险因素中

Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors

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