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首页> 外文期刊>Allergy >Biofilm propensity ofStaphylococcus aureusskin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort
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Biofilm propensity ofStaphylococcus aureusskin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort

机译：Biofilm Autaphyloccus Aureusskin分离物的倾向与MPAACH儿科队列的特征性皮炎严重程度和屏障功能障碍增加有关

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摘要

Background Atopic dermatitis (AD) patients are often colonized withStaphylococcus aureus,and staphylococcal biofilms have been reported on adult AD skin lesions. The commensalS epidermidiscan antagonizeS aureus, although its role in AD is unclear. We sought to characterizeS aureusandS epidermidiscolonization and biofilm propensity and determine their associations with AD severity, barrier function, and epidermal gene expression in the first US early-life cohort of children with AD, the Mechanisms of Progression of Atopic Dermatitis to Asthma in Children (MPAACH). Methods The biofilm propensity of staphylococcal isolates was assessed by crystal violet assays. Gene expression of filaggrin and antimicrobial alarminsS100A8andS100A9was measured in keratinocyte RNA extracted from skin tape strips. Staphylococcal biofilms sampled from MPAACH skin were visualized using scanning electron microscopy. Results Sixty-two percent of staphylococcal isolates (sampled from 400 subjects) formed moderate/strong biofilms. Sixty-eight percent of subjects co-colonized with both staphylococcal species exhibited strains that formed cooperative mixed-species biofilms. Scanning electron microscopy verified the presence of staphylococcal biofilms on the skin of MPAACH children.Staphylococcus aureusstrains showing higher relative biofilm propensity compared withS epidermidiswere associated with increased AD severity (P = .03) and increased lesional and nonlesional transepidermal water loss (P = .01,P = .03). Conclusions Our data suggest a pathogenic role forS aureusbiofilms in AD. We found that strain-level variation in staphylococcal isolates governs the interactions betweenS epidermidisandS aureusand that the balance between these two species, and their biofilm propensity, has important implications for AD.
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  • 来源
    《Allergy》 |2021年第1期|共12页
  • 作者

    Gonzalez Tammy; Stevens Mariana L.; Kyzy Asel Baatyrbek; Alarcon Rosario; He Hua; Kroner John W.; Spagna Daniel; Grashel Brittany; Sidler Elaine; Martin Lisa J.; Myers Jocelyn M. Biagini; Hershey Gurjit K. Khurana; Herr Andrew B.;

  • 作者单位

    Cincinnati Childrens Hosp Med Ctr Div Immunobiol 3333 Burnet Ave MLC 7038 Cincinnati OH 45229;

    Cincinnati Childrens Hosp Med Ctr Div Asthma Res 3333 Burnet Ave MLC 7037 Cincinnati OH 45229;

    Cincinnati Childrens Hosp Med Ctr Div Asthma Res 3333 Burnet Ave MLC 7037 Cincinnati OH 45229;

    Cincinnati Childrens Hosp Med Ctr Div Asthma Res 3333 Burnet Ave MLC 7037 Cincinnati OH 45229;

    Cincinnati Childrens Hosp Med Ctr Div Human Genet Cincinnati OH 45229 USA;

    Cincinnati Childrens Hosp Med Ctr Div Asthma Res 3333 Burnet Ave MLC 7037 Cincinnati OH 45229;

    Cincinnati Childrens Hosp Med Ctr Div Asthma Res 3333 Burnet Ave MLC 7037 Cincinnati OH 45229;

    Cincinnati Childrens Hosp Med Ctr Div Asthma Res 3333 Burnet Ave MLC 7037 Cincinnati OH 45229;

    Cincinnati Childrens Hosp Med Ctr Div Immunobiol 3333 Burnet Ave MLC 7038 Cincinnati OH 45229;

    Cincinnati Childrens Hosp Med Ctr Div Human Genet Cincinnati OH 45229 USA;

    Cincinnati Childrens Hosp Med Ctr Div Asthma Res 3333 Burnet Ave MLC 7037 Cincinnati OH 45229;

    Cincinnati Childrens Hosp Med Ctr Div Asthma Res 3333 Burnet Ave MLC 7037 Cincinnati OH 45229;

    Cincinnati Childrens Hosp Med Ctr Div Immunobiol 3333 Burnet Ave MLC 7038 Cincinnati OH 45229;

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  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    atopic dermatitis; biofilm; filaggrin; Staphylococcus aureus;

    机译：特应性皮炎;生物膜;Filaggrin;金黄色葡萄球菌;

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