Expanding the Chemical Diversity of Genetically Encoded Libraries

Sabrina E.  Iskandar; Victoria A.  Haberman; Albert A.  Bowers

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Expanding the Chemical Diversity of Genetically Encoded Libraries

机译：扩大遗传编码库的化学多样性

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摘要

The power of ribosomes has increasingly been harnessed for the synthesis and selection of molecular libraries. Technologies, such as phage display, yeast display, and mRNA display, effectively couple genotype to phenotype for the molecular evolution of high affinity epitopes for many therapeutic targets. Genetic code expansion is central to the success of these technologies, allowing researchers to surpass the intrinsic capabilities of the ribosome and access new, genetically encoded materials for these selections. Here, we review techniques for the chemical expansion of genetically encoded libraries, their abilities and limits, and opportunities for further development. Importantly, we also discuss methods and metrics used to assess the efficiency of modification and library diversity with these new techniques.

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《ACS combinatorial science》 |2020年第12期|共22页
作者
Sabrina E. Iskandar; Victoria A. Haberman; Albert A. Bowers;
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作者单位

Division of Chemical Biology and Medicinal Chemistry Eshelman School of Pharmacy University of North Carolina;

Division of Chemical Biology and Medicinal Chemistry Eshelman School of Pharmacy University of North Carolina;

Division of Chemical Biology and Medicinal Chemistry Eshelman School of Pharmacy University of North Carolina;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
genetically encoded libraries; peptide libraries; display technologies; quality control metrics; chemical modification; unnatural amino acids;

机译：遗传编码文库;肽文库;显示技术;质量控制指标;化学修饰;不自然的氨基酸;

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2. Genetic diversity center of cultivated soybean (Glycine max) in China——New insight and evidence for the diversity center of Chinese cultivated soybean [J] . WANG Li-xia, LIN Fan-yun, LI Lin-hai, 农业科学学报（英文版） . 2016,第011期
3. Genetic diversity center of cultivated soybean（Glycine max） in China——New insight and evidence for the diversity center of Chinese cultivated soybean [J] . WANG, Li-xia, LIN, 农业科学学报：英文版 . 2016,第011期
4. DNA-Encoded Library Chemistry: Amplification of Chemical Reaction Diversity for the Exploration of Chemical Space [J] . Ying Huang, Olena Savych, Yuii Moroz Aldrichimica acta . 2019,第3期

机译：DNA编码库化学：扩增化学空间探索的化学反应多样性
5. Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA genomes. [J] . Eric Delwart, Linlin Li Virus Research: An International Journal of Molecular and Cellular Virology . 2012,第1期

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6. Exploring Aldol Reactions on DNA and Applications to Produce Diverse Structures: An Example of Expanding Chemical Space of DNA-Encoded Compounds by Diversity-Oriented Synthesis [J] . Wu Rongfeng, Gao Sen, Du Tian, Chemistry, an Asian journal . 2020,第23期

机译：探索DNA和应用的aldol反应产生多样化的结构：通过定向定向的合成将DNA编码化合物的化学空间扩展的实例
7. Reversions from genetically unstable mutants as a means of expanding the genetic diversity of barley [C] . Vytautas Rancelis, Virginija Vaitkuniene, Laimute Balciuniene, European Association for Research on Plant Breeding General Congress . 2004

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8. Biased small molecule libraries: Encoding strategies, pathway development, and diversity -oriented synthesis [D] . Perez Fernandez, Lucy 2004

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9. Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids [O] . Frank J. Piscotta, Jeffery M. Tharp, Wenshe R. Liu, -1

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机译：摇摇欲坠的多样性：历史存档和当代自然种群的比较表明金莺莺的遗传多样性减少和遗传分化增加

Expanding the Chemical Diversity of Genetically Encoded Libraries

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