Virus-Mimicking Liposomal System Based on Dendritic Lipopeptides for Efficient Prevention Ischemia/Reperfusion Injury in the Mouse Liver

Rong  Zhuang; Mingqing  Chen; Yinhui  Zhou; Wenjing  Cheng; Tianhao  Zhang; Yifei  Ni; Chunhua  Guo; Jiasheng  Tu; Lei  Jiang

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Virus-Mimicking Liposomal System Based on Dendritic Lipopeptides for Efficient Prevention Ischemia/Reperfusion Injury in the Mouse Liver

机译：基于树突脂肽的病毒模拟脂质体系统，用于小鼠肝脏中有效预防缺血/再灌注损伤

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Hepatic ischemia-reperfusion injury (IRI) is a pathophysiological and huge challenge during liver surgical procedures. Herein, virus-mimicking liposomal system based on dendritic lipopeptides for efficient prevention of IRI is reported. These virus-mimicking liposomes not only have virus-like nanostructures and components, but also possess virus-like infections to liver tissue, liver cells, and organelles. The distinguished features for prevention of IRI of viral mimics are as follows: (i) viral envelope-like structure to help avoid the host immune system; (ii) well-defined nanostructure and surface to improve the accumulated efficiency in liver tissue; (iii) viral capsids mimic to enhance liver cell uptake and achieve mitochondrial targeting. This type of virus-mimicking design makes prevention of IRI by drug-loading greatly exceed the control groups with high biocompatibility and facile manufacturing.

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《ACS Macro Letters》 |2021年第2期|共8页
作者
Rong Zhuang; Mingqing Chen; Yinhui Zhou; Wenjing Cheng; Tianhao Zhang; Yifei Ni; Chunhua Guo; Jiasheng Tu; Lei Jiang;
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作者单位

Center for Research Development Evaluation of Pharmaceutical Excipients and Generic Drugs China Pharmaceutical University;

Center for Research Development Evaluation of Pharmaceutical Excipients and Generic Drugs China Pharmaceutical University;

Center for Research Development Evaluation of Pharmaceutical Excipients and Generic Drugs China Pharmaceutical University;

Center for Research Development Evaluation of Pharmaceutical Excipients and Generic Drugs China Pharmaceutical University;

Center for Research Development Evaluation of Pharmaceutical Excipients and Generic Drugs China Pharmaceutical University;

Center for Research Development Evaluation of Pharmaceutical Excipients and Generic Drugs China Pharmaceutical University;

Department of Radiology Southwest Hospital Third Military Medical University (Army Medical University);

Center for Research Development Evaluation of Pharmaceutical Excipients and Generic Drugs China Pharmaceutical University;

Center for Research Development Evaluation of Pharmaceutical Excipients and Generic Drugs China Pharmaceutical University;

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正文语种 eng
中图分类有机化学;
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1. Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress [J] . Vinicius Rocha-Santos, Estela RR Figueira, Joel A Rocha-Filho, 国际肝胆胰疾病杂志（英文版） . 2015,第002期
2. Remote ischemic preconditioning protects liver ischemia-reperfusion injury by regulating eNOS-NO pathway and liver microRNA expres-sions in fatty liver rats [J] . Yun-Fei Duan, Yong An, Feng Zhu, 国际肝胆胰疾病杂志（英文版） . 2017,第004期
3. The effects of ischemia-reperfusion injury and hepatic artery ischemia on CD14 expression in canine auto-transplantation livers [J] . Jinkai Xu, Yiming Li, Peijun Ye 生物医学研究杂志（英文版） . 2008,第003期
4. DNAX Activating Protein of 12 kDa/Triggering Receptor Expressed on Myeloid Cells 2 Expression by Mouse and Human Liver Dendritic Cells: Functional Implications and Regulation of Liver Ischemia–Reperfusion Injury [J] . Nakao Toshimasa, Ono Yoshihiro, Dai Helong, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2019,第2期

机译：12KDA /触发受体的DNAX活化蛋白在骨髓细胞2表达的粒细胞2表达中，通过小鼠和人肝树突细胞表达：功能影响和肝脏缺血再灌注损伤的调节
5. The fate of dendritic cells in a mouse model of liver ischemia/reperfusion injury. [J] . Loi P, Paulart F, Pajak B, Transplantation Proceedings . 2004,第5期

机译：树突状细胞在肝脏缺血/再灌注损伤小鼠模型中的命运。
6. Amelioration of cerebral ischemia-reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin [J] . Ishii T., Asai T., Oyama D., Journal of Controlled Release: Official Journal of the Controlled Release Society . 2012,第1期

机译：基于去脂促红细胞生成素脂质体给药系统改善脑缺血-再灌注损伤
7. Myocardial contrast echocardiography to assess perfusion in a mouse model of ischemia / reperfusion injury [C] . John A. Hossack, Yinbo Li, Jonathan P. Christensen, Ultrasonic Imaging and Signal Processing . 2004

机译：心肌对比超声心动图评估小鼠缺血/再灌注损伤模型中的灌注
8. Normothermic ex-situ Liver Perfusion and PPAR-γ Activation as Strategies to Reduce Liver Ischemia Reperfusion Injury [D] . Linares Cervantes, Iván de Jesús. 2019

机译：常温前肝灌注和PPAR-γ活化作为降低肝脏缺血再灌注损伤的策略
9. Dendritic Cell-Mediated Regulation of Liver Ischemia-Reperfusion Injury and Liver Transplant Rejection [O] . Ryosuke Nakano, Lillian M. Tran, David A. Geller, 2021

机译：树突细胞介导的肝脏缺血再灌注损伤调节和肝移植排斥反应
10. Virus-Mimicking Liposomal System Based on Dendritic Lipopeptides for Efficient Prevention Ischemia/Reperfusion Injury in the Mouse Liver [O] . -1

机译：基于树突脂肽的病毒模拟脂质体系统，用于小鼠肝脏有效预防缺血/再灌注损伤
11. Amelioration of Ischemia/Reperfusion Injury During Resuscitation from Hemorrhage by Induction of Heme Oxygenase-1 (HO-1) in a Conscious Mouse Model of Uncontrolled Hemorrhage. [R] . Bowman, P. 2012

机译：改良缺血/再灌注损伤在出血复苏过程中诱导血红素氧合酶-1（HO-1）在一个清醒的小鼠非控制性出血模型中的应用。

Virus-Mimicking Liposomal System Based on Dendritic Lipopeptides for Efficient Prevention Ischemia/Reperfusion Injury in the Mouse Liver

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