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首页> 外文期刊>ACS Macro Letters >Cationic Water-Soluble Pillar[5]arene-Modified Cu2–xSe Nanoparticles: Supramolecular Trap for ATP and Application in Targeted Photothermal Therapy in the NIR-II Window
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Cationic Water-Soluble Pillar[5]arene-Modified Cu2–xSe Nanoparticles: Supramolecular Trap for ATP and Application in Targeted Photothermal Therapy in the NIR-II Window

机译：阳离子水溶性柱[5]芳烯改性Cu2-XSE纳米颗粒：用于ATP的超分子疏水阀和在NIR-II窗口中靶向光热疗法的应用

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摘要

With the rapid progress of nanotechnology, near-infrared (NIR), light-assisted phototherapy as a minimally invasive local cancer therapy, especially photothermal therapy (PTT), has captured broad research attention in recent years. However, combined target molecules with a PTT system through reversible supramolecular interactions has been reported rarely. In this work, we constructed a supramolecular nanosystem combining ATP capture and target PTT based on cationic pillar[5]arene (CWP5)-functionalized Cu_(2–x )Se nanoparticles (Cu_(2–x )[email?protected] NPs). Cu_(2–x )[email?protected] NPs, with an average diameter of approximately 100 nm and strong absorption in the near-infrared-II window, were prepared in water through a facile one-step in situ synthesis method, then (4-carboxybutyl)triphenylphosphonium bromide (TPP), a mitochondria-targeted molecule, was modified on the surface of the particles through the host–guest recognition. Upon irradiation with a 1064 nm laser, the obtained Cu_(2–x )[email?protected]/TPP NPs showed remarkably photothermal ablation capability to HeLa cells. Importantly, our Cu_(2–x )[email?protected]/TPP NPs exhibited excellent therapeutic effect due to the combination of inhibited hydrolysis of ATP and targeted photothermal therapy upon in vitro and in vivo studies.
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  • 来源
    《ACS Macro Letters》 |2020年第11期|共5页
  • 作者

    Moupan Cen; Yue Ding; Jin Wang; Xiaolei Yuan; Bing Lu; Yang Wang; Yong Yao;

  • 作者单位

    School of Chemistry and Chemical Engineering Nantong University;

    School of Chemistry and Chemical Engineering Nantong University;

    School of Chemistry and Chemical Engineering Nantong University;

    School of Chemistry and Chemical Engineering Nantong University;

    School of Chemistry and Chemical Engineering Nantong University;

    School of Chemistry and Chemical Engineering Nantong University;

    School of Chemistry and Chemical Engineering Nantong University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 有机化学;
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