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首页> 外文期刊>ACS Macro Letters >Three-Dimensional Printable Gelatin Hydrogels Incorporating Graphene Oxide to Enable Spontaneous Myogenic Differentiation
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Three-Dimensional Printable Gelatin Hydrogels Incorporating Graphene Oxide to Enable Spontaneous Myogenic Differentiation

机译：掺入石墨烯氧化物的三维可印刷明胶水凝胶，使自发性肌源性分化

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摘要

Three-dimensional (3D) bioprinting has attracted considerable attention for producing 3D engineered cellular microenvironments that replicate complex and sophisticated native extracellular matrices (ECM) as well as the spatiotemporal gradients of numerous physicochemical and biological cues. Although various hydrogel-based bioinks have been reported, the development of advanced bioink materials that can reproduce the complexity of ECM accurately and mimic the intrinsic property of laden cells is still a challenge. This paper reports 3D printable bioinks composed of phenol-rich gelatin (GHPA) and graphene oxide (GO) as a component for a myogenesis-inducing material, which can form a hydrogel network in situ by a dual enzyme-mediated cross-linking reaction. The in situ curable GO/GHPA hydrogel can be utilized successfully as 3D-printable bioinks to provide suitable cellular microenvironments with facilitated myogenic differentiation of C2C12 skeletal myoblasts. Overall, we suggest that functional bioinks may be useful in muscle tissue engineering and regenerative medicine.
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  • 来源
    《ACS Macro Letters》 |2021年第4期|共7页
  • 作者

    Kang Moon Sung; Kang Jeon Il; Thi Phuong Le; Park Kyung Min; Hong Suck Won; Choi Yu Suk; Han Dong-Wook; Park Ki Dong;

  • 作者单位

    Pusan Natl Univ Dept Cognomechatron Engn Busan 46241 South Korea;

    Incheon Natl Univ Dept Bioengn &

    Nanobioengn Incheon 22012 South Korea;

    Ajou Univ Dept Mol Sci &

    Technol Suwon 16499 South Korea;

    Incheon Natl Univ Dept Bioengn &

    Nanobioengn Incheon 22012 South Korea;

    Pusan Natl Univ Dept Cognomechatron Engn Busan 46241 South Korea;

    Univ Western Australia Sch Human Sci Perth WA 6009 Australia;

    Pusan Natl Univ Dept Cognomechatron Engn Busan 46241 South Korea;

    Ajou Univ Dept Mol Sci &

    Technol Suwon 16499 South Korea;

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  • 正文语种 eng
  • 中图分类 有机化学;
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