Nanocapsules Produced by Nanoprecipitation of Designed Suckerin-Silk Fusion Proteins

Ramos Ricardo; Koh Kenrick; Gabryelczyk Bartosz; Chai Luxiao; Kanagavel Deepankumar; Yan Xibo; Ganachaud Francois; Miserez Ali; Bernard Julien

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Nanocapsules Produced by Nanoprecipitation of Designed Suckerin-Silk Fusion Proteins

机译：由设计的Suckerin-Liment蛋白的纳米沉淀产生的纳米胶囊

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Herein, we report on the precise design of a modular fusion protein amenable to the construction of nanocapsules by nanoprecipitation. The central squid suckerin-derived peptide block provides structural stability, whereas both termini from spider silk fibroins make the protein highly soluble at physiological pH, a critical requirement for the nanoprecipitation process. With this design, nanocapsules consisting of fusion protein shells and oily cores with sizes in the range of 190-250 nm are built in a straightforward manner.

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《ACS Macro Letters》 |2021年第5期|共7页
作者
Ramos Ricardo; Koh Kenrick; Gabryelczyk Bartosz; Chai Luxiao; Kanagavel Deepankumar; Yan Xibo; Ganachaud Francois; Miserez Ali; Bernard Julien;
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作者单位

Univ Lyon CNRS INSA Lyon IMP UMR 5223 F-69622 Villeurbanne France;

Nanyang Technol Univ NTU Ctr Sustainable Mat Sch Mat Sci &

Engn Singapore 637553 Singapore;

Nanyang Technol Univ NTU Ctr Sustainable Mat Sch Mat Sci &

Engn Singapore 637553 Singapore;

Univ Lyon CNRS INSA Lyon IMP UMR 5223 F-69622 Villeurbanne France;

Nanyang Technol Univ NTU Ctr Sustainable Mat Sch Mat Sci &

Engn Singapore 637553 Singapore;

Univ Lyon CNRS INSA Lyon IMP UMR 5223 F-69622 Villeurbanne France;

Univ Lyon CNRS INSA Lyon IMP UMR 5223 F-69622 Villeurbanne France;

Nanyang Technol Univ NTU Ctr Sustainable Mat Sch Mat Sci &

Engn Singapore 637553 Singapore;

Univ Lyon CNRS INSA Lyon IMP UMR 5223 F-69622 Villeurbanne France;

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正文语种 eng
中图分类有机化学;
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Nanocapsules Produced by Nanoprecipitation of Designed Suckerin-Silk Fusion Proteins

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