Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion

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Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion

机译：尾锚膜蛋白靶向和插入的机制

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Proper localization of membrane proteins is essential for the function of biological membranes and for the establishment of organelle identity within a cell. Molecular machineries that mediate membrane protein biogenesis need to not only achieve a high degree of efficiency and accuracy, but also prevent off-pathway aggregation events that can be detrimental to cells. The posttranslational targeting of tail-anchored proteins (TAs) provides tractable model systems to probe these fundamental issues. Recent advances in understanding TA-targeting pathways reveal sophisticated molecular machineries that drive and regulate these processes. These findings also suggest how an interconnected network of targeting factors, cochaperones, and quality control machineries together ensures robust membrane protein biogenesis.

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《Annual review of cell and developmental biology》 |2017年第2017期|共22页
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正文语种 eng
中图分类细胞生物学;
关键词
tail-anchored protein; protein targeting; ATPase; membrane protein biogenesis; chaperones; protein quality control;

机译：尾锚蛋白;蛋白质靶向;ATP酶;膜蛋白生物发生;伴侣;蛋白质质量控制;

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4. Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion [J] . Annual review of cell and developmental biology . 2017,第期

机译：尾锚膜蛋白靶向和插入的机制
5. Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins. [J] . Favaloro V, Spasic M, Schwappach B, Journal of Cell Science . 2008,第Pta11期

机译：尾锚（TA）蛋白质膜插入的不同靶向途径。
6. The mechanism of membrane-associated steps in tail-anchored protein insertion [J] . Malaiyalam Mariappan, Agnieszka Mateja, Malgorzata Dobosz, Nature . 2011,第7362期

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7. Co-translational Protein Processing, Folding, Targeting, and Membrane Insertion of Newly Synthesized Proteins [C] . Daniel Boehringer, Nenad Ban Macromolecular crystallography: deciphering the structure, function and dynamics of biological molecules . 2010

机译：新合成蛋白的共翻译蛋白加工，折叠，靶向和膜插入
8. Characterization of the targeting and membrane insertion of mitochondrial tombusvirus replication proteins and tail-anchored proteins . [D] . Hwang, Yeen Ting. 2010

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10. In vitro Assays for Targeting and Insertion of Tail-Anchored Proteins Into the ER Membrane [O] . Hyunju Cho, Un Seng Chio, Shu-ou Shan 2018

机译：用于靶向和插入尾翼锚定蛋白的体外测定进入ER膜
11. Development of Helios Target Insertion Mechanism [R] . Day, R. D., Cummings, C. E., Tucker, H. E. 1979

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Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion

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