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首页> 外文期刊>Anti-infective agents >Telfairia occidentalis Potentiates the Antiplasmodial Activity of Artemisinins and Amodiaquine Combination Therapy | Bentham Science
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Telfairia occidentalis Potentiates the Antiplasmodial Activity of Artemisinins and Amodiaquine Combination Therapy | Bentham Science

机译：Telfairia occidentalis增强了青蒿素的抗溶质活性和氨基喹组合治疗 Bentham Science.

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摘要

Drug-phytochemical interactions sometimes result in various unpredictable outcomes.Objectives: The aim of this study was to evaluate the in vivo antiplasmodial activity of the aqueous leaf extractof Telfairia occidentalis and its potentiation of the activity of Amodiaquine (AQ) and dihydroartemisinin(DHA) on mice infected with Plasmodium berghei.Methods: Phytochemical screening of the extract was carried out using standard procedures. The extractprepared in 250 and 500 mg/kg/body weight together with amodiaquine and dihydroartemisinin were administeredas a single dose and in combination to albino mice by oral gavage, adopting the standard proceduresof prophylactic, suppressive and curative antiplasmodial assay models.Results: Phytochemical screening of the extract confirms the abundance of alkaloids, saponins and tannins.The analysis reveals a significant (p < 0.05) competitive reduction of parasitaemia by the conventionaldrugs and the extract in a dose-dependent order. The aqueous extract of T. occidentalis at 250 and 500mg/kg gave a percentage parasitaemia reduction of 83.90 % and 85.00%, respectively when comparedwith the negative control. The concurrent administration of the extract and the drugs produced a synergisticeffect in a dose-dependent order. When AQ plus DHA waer administered concurrently with 250 mg/kgand 500 mg/kg of extract, the percentage reduction in parasitaemia increased to 99.50 % and 99.59%, respectively.Conclusion: This shows that the aqueous extract of T. occidentalis possesses significant (p < 0.05) antiplasmodialactivity which is comparable to AQ and DHA. It also enhances the efficacy of the standarddrugs which indicates an advantage in the treatment of uncomplicated falciparum malaria.
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