Dendritic Cell Regulation of T Helper Cells

Yin Xiangyun; Chen Shuting; Eisenbarth Stephanie C.

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Dendritic Cell Regulation of T Helper Cells

机译：T辅助细胞的树突状细胞调节

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摘要

As the professional antigen-presenting cells of the immune system, dendritic cells (DCs) sense the microenvironment and shape the ensuing adaptive immune response. DCs can induce both immune activation and immune tolerance according to the peripheral cues. Recent work has established that DCs comprise several phenotypically and functionally heterogeneous subsets that differentially regulate T lymphocyte differentiation. This review summarizes both mouse and human DC subset phenotypes, development, diversification, and function. We focus on advances in our understanding of how different DC subsets regulate distinct CD4(+) T helper (Th) cell differentiation outcomes, including Th1, Th2, Th17, T follicular helper, and T regulatory cells. We review DC subset intrinsic properties, local tissue microenvironments, and other immune cells that together determine Th cell differentiation during homeostasis and inflammation.

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来源
《Annual Review of Immunology》 |2021年第1期|共32页
作者
Yin Xiangyun; Chen Shuting; Eisenbarth Stephanie C.;
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作者单位

Yale Univ Sch Med Dept Lab Med 333 Cedar St New Haven CT 06520 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
dendritic cells; Th1 cells; Th2 cells; Th17 cells; Treg cells; Tfh cells;

机译：树突状细胞;TH1细胞;TH2细胞;TH17细胞;TREG细胞;TFH细胞;

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2. Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses [J] . Kerry L.Hilligan, Franca Ronchese 细胞与分子免疫学：英文版 . 2020,第006期
3. Insights on the crosstalk between dendritic cells and helper T cells in novel genetic etiology for mendelian susceptible mycobacterial disease [J] . Emma Rey-Jurado, Magdalena S.Pizarro-Ortega, Alexis M.Kalergis 细胞与分子免疫学：英文版 . 2018,第012期
4. IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes [J] . Huifen Zhu, Wenhong Qiu, Ping Lei, 细胞与分子免疫学：英文版 . 2008,第001期
5. IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes [J] . Huifen Zhu, Feili Gong, Wenhong Qiu, 中国免疫学杂志（英文版） . 2008,第001期
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机译：病原体相关的分子模式诱导树突细胞，T辅助细胞和天然杀伤辅助细胞之间的串扰可以改善树突细胞疫苗接种
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机译：暴露于蛋白质和接触性过敏原后，人树突状细胞中促进T辅助1和T辅助2促进细胞因子信号传导因子的不同调节。
8. Differential regulation of Notch ligands in dendritic cells upon interaction with T helper cells. [J] . Sauma D, Espejo P, Ramirez A, Scandinavian journal of immunology. . 2011,第1期

机译：与T辅助细胞相互作用后，树突状细胞中Notch配体的差异调节。
9. The relationship between Salmonella plasmid virulence genes and dendritic cells autophagy, apoptosis and immune regulation [C] . Li YY, Wu SY, Chu YY, International symposium on bacterial genomics, evolution and pathogenesis. . 2010

机译：沙门氏菌质粒毒力基因与树突状细胞自噬，凋亡和免疫调节的关系
10. Aging dendritic cell function and effects on T helper cell differentiation [D] . Myer, Rebecca G. 2008

机译：树突状细胞的功能及其对T辅助细胞分化的影响
11. Pathogen-Associated Molecular Patterns Induced Crosstalk between Dendritic Cells T Helper Cells and Natural Killer Helper Cells Can Improve Dendritic Cell Vaccination [O] . Tammy Oth, Joris Vanderlocht, Catharina H. M. J. Van Elssen, 2016

机译：病原相关的分子模式诱导树突状细胞T辅助细胞和自然杀伤辅助细胞之间的串扰可以改善树突状细胞的疫苗接种
12. Different regulation of T helper 1- and T helper 2-promoting cytokine signalling factors in human dendritic cells after exposure to protein versus contact allergens [O] . Böttcher, Ingo, Bellinghausen, Iris, König, Bettina, 2008

机译：接触蛋白质和接触过敏原后，人树突状细胞中T辅助1和T辅助2促进细胞因子信号传导因子的不同调节
13. Lactobacilli Activate Human Dendritic Cells that Skew T Cells Toward T Helper 1 Polarization [R] . Mohamadzadeh, M. , Olson, S. , Kalina, W. V. , 2005

机译：乳酸杆菌激活人类树突状细胞，使T细胞向T辅助细胞1极化倾斜

Dendritic Cell Regulation of T Helper Cells

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