Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies

Jacobsen Elizabeth A.; Jackson David J.; Heffler Enrico; Mathur Sameer K.; Bredenoord Albert J.; Pavord Ian D.; Akuthota Praveen; Roufosse Florence; Rothenberg Marc E.

首页> 外文期刊>Annual Review of Immunology >Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies

【24h】

Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies

机译：嗜酸性粒细胞敲除人类：通过嗜酸性粒细胞导向的生物疗法揭示嗜酸性粒细胞的作用

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo, initially in mice andmore recently in humans. Researchers using eosinophil knockout mice have identified a contributory role for eosinophils in basal and inflammatory processes and protective immunity. Primarily fueled by the purported proinflammatory role of eosinophils in eosinophil-associated diseases, a series of anti-eosinophil therapeutics have emerged as a new class of drugs. These agents, which dramatically deplete eosinophils, provide a valuable opportunity to characterize the consequences of eosinophil knockout humans. Herein, we comparatively describe mouse and human eosinophil knockouts. We put forth the view that human eosinophils negatively contribute to a variety of diseases and, unlikemouse eosinophils, do not yet have an identified role in physiological health; thus, clarifying all roles of eosinophils remains an ongoing pursuit.

机译：None

著录项

来源
《Annual Review of Immunology》 |2021年第1期|共39页
作者
Jacobsen Elizabeth A.; Jackson David J.; Heffler Enrico; Mathur Sameer K.; Bredenoord Albert J.; Pavord Ian D.; Akuthota Praveen; Roufosse Florence; Rothenberg Marc E.;
展开▼
作者单位

Mayo Clin Div Allergy Asthma &

Clin Immunol Scottsdale AZ 85259 USA;

Guys &

St Thomas Hosp London WC2R 2LS England;

Humanitas Univ Dept Biomed Sci I-20090 Milan Italy;

Univ Wisconsin Sch Med &

Publ Hlth Dept Med Div Allergy Pulm &

Crit Care Med Madison WI 53792;

Univ Amsterdam Amsterdam UMC Dept Gastroenterol &

Hepatol NL-1105 AZ Amsterdam Netherlands;

Oxford Resp NIHR BRC Nuffield Dept Med Resp Med Unit Oxford OX3 9DU England;

Univ Calif San Diego Dept Med Div Pulm Crit Care &

Sleep Med La Jolla CA 92093 USA;

Univ Libre Bruxelles Hop Erasme Med Interne B-1070 Brussels Belgium;

Univ Cincinnati Coll Med Cincinnati Childrens Hosp Med Ctr Div Allergy &

Immunol Dept Pediat;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
eosinophil; eosinophil knockout; biologic agents; eosinophil-deficient mice; eosinophil-associated diseases; IL-5;

机译：嗜酸性粒细胞;嗜酸性粒细胞敲除;生物学剂;嗜酸性粒细胞缺乏小鼠;嗜酸性粒细胞相关疾病;IL-5;

相似文献

外文文献
中文文献
专利

1. Effect of RNA interference therapy on the mice eosinophils CCR3 gene and granule protein in the murine model of allergic rhinitis [J] . Xin-Hua Zhu, Bing Liao, Ke Liu, 亚太热带医药杂志（英文版） . 2014,第003期
2. Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation [J] . Joyce YS Chow, Chun K Wong, Phyllis FY Cheung, 中国免疫学杂志（英文版） . 2010,第001期
3. Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation [J] . Joyce YS Chow, Chun K Wong, Phyllis FY Cheung, 细胞与分子免疫学：英文版 . 2010,第001期
4. Multiple Biological Aspects of Eosinophils in Host Defense, Eosinophil-Associated Diseases, Immunoregulation, and Homeostasis: Is Their Role Beneficial, Detrimental, Regulator, or Bystander? [J] . Kanda Akira, Yasutaka Yun, Dan Van Bui, Biological & pharmaceutical bulletin . 2020,第1期

机译：嗜酸性粒细胞的多种生物学方面在宿主防御，嗜酸性粒细胞相关疾病，免疫调节和稳态：是它们有益，有害的，调节剂或旁观者的作用？
5. The enigmatic eosinophil: investigation of the biological role of eosinophils in parasitic helmint infection [J] . Carolyn A Behm, Karen S Ovington Memórias do Instituto Oswaldo Cruz . 1997,第92期

机译：神秘的嗜酸性粒细胞：嗜酸性粒细胞在寄生性蠕虫感染中的生物学作用的研究
6. The Enigmatic Eosinophil: Investigation Of The Biological Role Of Eosinophils In Parasitic Helmint Infection [J] . Ovington Karen S. Behm Carolyn A. Memorias do Instituto Oswaldo Cruz . 1997,第s2期

机译：神秘的嗜酸性粒细胞：嗜酸性粒细胞在寄生性蠕虫感染中的生物学作用的调查。
7. Sputum Eosinophil Counts and Eosinophil Cationic Protein (ECP) Levels in Cough-Variant Asthma and in Classic Asthma, and Their Relationships to Airway Hypersensitivity or Maximal Airway Response to Methacholine [C] . Young Yoo, Young Yull Koh, Hee Kang Asia Pacific Congress of Allergology and Clinical Immunology . 2004

机译：痰嗜酸性粒细胞计数和嗜酸铈粒细胞阳离子蛋白（ECP）水平在咳嗽变异哮喘和经典的哮喘，以及它们与气道超敏反应或最大气道对甲磺酸的关系的关系
8. The role of the JAK/STAT signal transduction pathway in the biology of the human eosinophil. [D] . Stout, Barbara Anne. 2003

机译：JAK / STAT信号转导途径在人类嗜酸性粒细胞生物学中的作用。
9. Biologic Therapies Targeting Eosinophils: Current Status and Future Prospects [O] . Fanny Legrand, Amy Klion -1

机译：针对嗜酸性粒细胞的生物疗法：现状和未来展望
10. Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies [O] . Elizabeth A. Jacobsen, David J. Jackson, Enrico Heffler, 2021

机译：嗜酸性粒细胞敲除人类：通过嗜酸性粒细胞导向的生物疗法揭示嗜酸性粒细胞的作用
11. Regulation of Human Eosinophil Adhesion in Allergic Inflammation [R] . Bochner, B. S. , Matsumoto, K. , Sterbinsky, S. A. , 1999

机译：人嗜酸性粒细胞粘附在过敏性炎症中的调节

Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies

摘要

著录项

相似文献

相关主题

期刊订阅