The Use of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia

Ashley M. Novotny; Pamela A. Harris-Haman; Ksenia Zukowsky

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The Use of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia

机译：在先天性膈疝中使用吸入的一氧化氮

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Background: Congenital diaphragmatic hernia (CDH) is a complex congenital defect of the diaphragm that allows abdominal contents to herniate into the chest cavity, altering pulmonary development, and leading to pulmonary hypoplasia and hypertension. Patient presentation is variable in severity, making management difficult. Many common management strategies have improved the survival rate of infants with CDH, including gentle ventilation and permissive hypercapnia. Inhaled nitric oxide (iNO) is a potent, pulmonary vasodilator that has shown to improve oxygenation while decreasing pulmonary pressure in infants with pulmonary hypertension. While many institutions utilize iNO in the treatment of pulmonary hypertension, the role of iNO as a treatment for CDH is controversial. Purpose: The purpose of this literature review is to establish a better understanding of CDH including embryology, patient presentation, and management strategies, and to analyze the use and effect of iNO on patients in this population. Methods/Search Strategy: A systemic search of PubMed, CINHAL, and Medline was performed to identify research articles studying the use of iNO on patients with pulmonary hypertension secondary to CDH. Findings/Results: Three studies were utilized in this review to assess the current use and effectiveness of iNO in patients with CDH. Implications for Practice: This review summarized the pathophysiology, embryology, patient presentation, and management strategies, as well as reviewed literature on the effectiveness of iNO on pulmonary hypertension secondary to CDH. Implications for Research: Further research is indicated to determine alternative treatment modalities and establish evidence-based practice protocols to standardize care in infants with CDH.

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《Advances in neonatal care: official journal of the National Association of Neonatal Nurses》 |2020年第6期|共8页
作者
Ashley M. Novotny; Pamela A. Harris-Haman; Ksenia Zukowsky;
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作者单位

Neonatal Intensive Care Unit Children's Hospital Colorado-Colorado Springs and Regis University;

Neonatal Intensive Care Unit Children's Hospital Colorado-Colorado Springs and Regis University;

Neonatal Intensive Care Unit Children's Hospital Colorado-Colorado Springs and Regis University;

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正文语种 eng
中图分类儿科学;
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2. Nitric oxide inhalation inhibits inducible nitric oxide synthase but not nitrotyrosine formation and cell apoptosis in rat lungs with meconium-induced injury [J] . Mei-ping LU, Li-zhong DU, Wei-zhong GU, 中国药理学报：英文版 . 2005,第009期
3. Predicting Perinatal Outcomes in Fetuses with Congenital Diaphragmatic Hernia Using Ultrasound and Magnetic Resonance Imaging [J] . Jun Huang, Hongli Liu, Haiyan Hu, 母胎医学杂志（英文） . 2021,第004期
4. A report on the congenital hepatic diaphragmatic hernia [J] . Hou-Gan Ouyang, Zhi-Dong Zhao, Wen-Jing Lu, 中华医学杂志（英文版） . 2021,第002期
5. Pathophysiology of congenital diaphragmatic hernia. VIII: Inhaled nitric oxide requires exogenous surfactant therapy in the lamb model of congenital diaphragmatic hernia. [J] . Karamanoukian HL, Glick PL, Wilcox DT, Journal of Pediatric Surgery: Official Journal of the Surgical Section of the American Academy of Pediatric, the British Association of Paediatric Surgeons, the American Pediatric Surgical Association, and the Canadian Association of Paediatric Surgeons . 1995,第1期

机译：先天性膈疝的病理生理学。 VIII：吸入一氧化氮需要在先天性膈疝的羊羔模型中进行外源性表面活性剂治疗。
6. Pathophysiology of congenital diaphragmatic hernia. X: Localization of nitric oxide synthase in the intima of pulmonary artery trunks of lambs with surgically created congenital diaphragmatic hernia. [J] . Karamanoukian HL, Glick PL, Wilcox DT, Journal of Pediatric Surgery: Official Journal of the Surgical Section of the American Academy of Pediatric, the British Association of Paediatric Surgeons, the American Pediatric Surgical Association, and the Canadian Association of Paediatric Surgeons . 1995,第1期

机译：先天性diaphragm肌疝的病理生理学。 X：一氧化氮合酶在具有手术产生的先天性diaphragm肌疝气的羔羊的肺动脉干内膜中的定位。
7. Pathophysiology of congenital diaphragmatic hernia. X: Localization of nitric oxide synthase in the intima of pulmonary artery trunks of lambs with surgically created congenital diaphragmatic hernia. [J] . Karamanoukian HL, Glick PL, Wilcox DT, Journal of Pediatric Surgery: Official Journal of the Surgical Section of the American Academy of Pediatric, the British Association of Paediatric Surgeons, the American Pediatric Surgical Association, and the Canadian Association of Paediatric Surgeons . 1995,第1期

机译：先天性diaphragm肌疝的病理生理学。 X：一氧化氮合酶在具有手术产生的先天性diaphragm肌疝气的羔羊的肺动脉干内膜中的定位。
8. Inhalation of nitric oxide in congenital heart defects associated with pulmonary hypertension. [C] . Acta pharmacologica sinica . 2002

机译：一氧化氮吸入与肺动脉高压相关的先天性心脏缺陷。
9. Investigating the mechanisms underlying congenital diaphragmatic hernia and lung maturation. [D] . Branchfield, Kelsey. 2015

机译：研究先天性diaphragm肌疝和肺成熟的潜在机制。
10. The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia [O] . Suzan Cochius-den Otter, Thomas Schaible, Anne Greenough, 2019

机译：CoDiNOS试验方案：静脉西地那非与吸入一氧化氮治疗先天性diaphragm肌疝新生儿的肺动脉高压的国际随机对照试验
11. Initial Oxygenation Response to Inhaled Nitric Oxide Predicts Improved Outcome in Congenital Diaphragmatic Hernia [O] . 2014

机译：吸入一氧化氮的初始氧合反应可预测先天性ph肌疝的改善结果。
12. Effect of Inhaled Nitric Oxide on Smoke Inhalation Injury in an Ovine Model [R] . Ogura, H., Cioffi, W. G., Jordan, B. S., 1994

机译：吸入一氧化氮对绵羊模型烟雾吸入伤害的影响

The Use of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia

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