...
首页> 外文期刊>EMBO reports >Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion
【24h】

Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion

机译:视网膜母细胞瘤蛋白促进子宫上皮细胞周期停滞和胚胎侵袭

获取原文
获取原文并翻译 | 示例
           

摘要

Retinoblastoma protein (RB) encoded by Rb1 is a prominent inducer of cell cycle arrest (CCA). The hormone progesterone (P-4) promotes CCA in the uterine epithelium and previous studies indicated that P-4 activates RB by reducing the phosphorylated, inactive form of RB. Here, we show that embryo implantation is impaired in uterine-specific Rb1 knockout mice. We observe persistent cell proliferation of the Rb1-deficient uterine epithelium until embryo attachment, loss of epithelial necroptosis, and trophoblast phagocytosis, which correlates with subsequent embryo invasion failure, indicating that Rb1-induced CCA and necroptosis of uterine epithelium are involved in embryo invasion. Pre-implantation P-4 supplementation is sufficient to restore these defects and embryo invasion. In Rb1-deficient uterine epithelial cells, TNF alpha-primed necroptosis is impaired, which is rescued by the treatment with a CCA inducer thymidine or P-4 through the upregulation of TNF receptor type 2. TNF alpha is expressed in the luminal epithelium and the embryo at the embryo attachment site. These results provide evidence that uterine Rb1-induced CCA is involved in TNF alpha-primed epithelial necroptosis at the implantation site for successful embryo invasion.
机译:None

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号