CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2

Xie Peiyi; Wang Hui; Fang Jiayu; Du Dongnian; Tian Ze; Zhen Jing; Liu Yue; Ding Yongqi; Fu Bidong; Liu Fanrong; Huang Da; Yu Jichun

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CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2

机译：CSN5通过Angptl2促进甲状腺癌细胞的致癌物

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COP9 signalosome subunit 5 (CSN5) plays a key role in carcinogenesis of multiple cancers and contributes to the stabilization of target proteins through deubiquitylation. However, the underlying role of CSN5 in thyroid carcinoma has not been reported. In this research, our data showed that CSN5 was overexpressed in thyroid carcinoma tissues compared with paracancerous tissues. Furthermore, a series of gain/loss functional assays were performed to demonstrate the role of CSN5 in facilitating thyroid carcinoma cell proliferation and metastasis. Additionally, we found there was a positive correlation between CSN5 and angiopoietin-like protein 2 (ANGPTL2) protein levels in thyroid carcinoma tissues and that CSN5 promoted thyroid carcinoma cell proliferation and metastasis through ANGPTL2. We also identified the underlying mechanism that CSN5 elevated ANGPTL2 protein level by directly binding it, decreasing its ubiquitination and degradation. Overall, our results highlight the significance of CSN5 in promoting thyroid carcinoma carcinogenesis and implicate CSN5 as a promising candidate for thyroid carcinoma treatment.

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来源
《Endocrinology》 |2021年第3期|共12页
作者
Xie Peiyi; Wang Hui; Fang Jiayu; Du Dongnian; Tian Ze; Zhen Jing; Liu Yue; Ding Yongqi; Fu Bidong; Liu Fanrong; Huang Da; Yu Jichun;
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作者单位

Nanchang Univ Affiliated Hosp 2 Dept Gen Surg Nanchang 330006 Jiangxi Peoples R China;

Shanghai Jiao Tong Univ Sch Med Dept Endocrinol &

Metab China Natl Res Ctr Metab Dis Shanghai;

Nanchang Univ Coll Clin Med 2 Nanchang 330006 Jiangxi Peoples R China;

Nanchang Univ Affiliated Hosp 2 Dept Gen Surg Nanchang 330006 Jiangxi Peoples R China;

Nanchang Univ Coll Clin Med 2 Nanchang 330006 Jiangxi Peoples R China;

Nanchang Univ Coll Clin Med 2 Nanchang 330006 Jiangxi Peoples R China;

Nanchang Univ Coll Clin Med 2 Nanchang 330006 Jiangxi Peoples R China;

Nanchang Univ Coll Clin Med 2 Nanchang 330006 Jiangxi Peoples R China;

Nanchang Univ Coll Clin Med 2 Nanchang 330006 Jiangxi Peoples R China;

Nanchang Univ Affiliated Hosp 2 Dept Pathol Nanchang 330006 Jiangxi Peoples R China;

Nanchang Univ Affiliated Hosp 2 Dept Thyroid Surg 1 Minde Rd Nanchang 330006 Jiangxi Peoples;

Nanchang Univ Affiliated Hosp 2 Dept Thyroid Surg 1 Minde Rd Nanchang 330006 Jiangxi Peoples;

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原文格式 PDF
正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
CSN5; ANGPTL2; thyroid carcinoma; proliferation; migration; invasion;

机译：CSN5;Angptl2;甲状腺癌;增殖;迁移;入侵;

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专利

1. Downregulating integrin subunit alpha 7 (ITGA7) promotes proliferation, invasion, and migration of papillary thyroid carcinoma cells through regulating epithelial-to-mesenchymal transition [J] . Yaoyao Guan, Adheesh Bhandari, Erjie Xia, 生物化学与生物物理学报：英文版 . 2020,第002期
2. Insulin-like growth factor-1 promotes cell cycle progression via upregulation of cyclin D1 expression through the phosphatidy-linositol 3-kinaseuclear factor-κB signaling pathway in FRTL thyroid cells [J] . Meng REN, Xia ZHONG, Chun-yan MA, 中国药理学报：英文版 . 2009,第001期
3. In the Basis of Hashimoto’s Thyroiditis, to Form Papillary Thyroid Carcinoma, Metastasized and Then to De-Differentiate into Poorly Differentiated Squamous Cell Carcinoma [J] . Xinle Ren, Di Zhu, Hen Wang, 癌症治疗（英文） . 2021,第005期
4. Correlation of S100A13 and FOXA1 expression with cell cycle and cell invasion in fine needle aspiration thyroid carcinoma tissue [J] . Yin Yue-Ling, Xiao-Dong Yu 海南医科大学学报（英文版） . 2018,第001期
5. CSN5 promotes renal cell carcinoma metastasis and EMT by inhibiting ZEB1 degradation [J] . Zhang Shouhua, Hong Zhengdong, Chai Yong, Biochemical and Biophysical Research Communications . 2017,第1期

机译：CSN5通过抑制Zeb1降解促进肾细胞癌转移和EMT
6. Disruption of transforming growth factor-β signaling in thyroid follicular epithelial cells or intrathyroidal fibroblasts does not promote thyroid carcinogenesis [J] . Mika Shimamura, Mami Nakahara, Tomomi Kurashige, Endocrine journal . 2014,第3期

机译：甲状腺滤泡上皮细胞或甲状腺内成纤维细胞中转化生长因子-β信号的破坏不会促进甲状腺癌变
7. Disruption of transforming growth factor-β signaling in thyroid follicular epithelial cells or intrathyroidal fibroblasts does not promote thyroid carcinogenesis [J] . Kazuaki Yasui, Mami Nakahara, Masahiro Nakashima, Endocrine journal . 2014,第3期

机译：甲状腺滤泡上皮细胞或甲状腺内成纤维细胞中转化生长因子-β信号的破坏不会促进甲状腺癌变
8. SIMULATED MICROGRAVITY INDUCES PROGRAMMED CELL DEATH IN HUMAN THYROID CARCINOMA CELLS [C] . Peter Kossmehl, Mehdi Shakibaei, Augusto Cogoli, 8th European Symposium Life Sciences Research in Space and 23rd Annual International Gravitational Physiology Meeting Jun 2-7, 2002 Stockholm, Sweden . 2002

机译：模拟的微重力诱导人甲状腺癌细胞中的程序性细胞死亡
9. Phosphatidylinositol Remodeling Through Membrane Bound O-Acyl Transferase Domain-7 (MBOAT7) Promotes the Progression of Clear Cell Renal Cell Carcinoma (ccRCC) [D] . Neumann, Chase K. A. 2020

机译：通过膜结合的磷脂酰肌醇通过膜结合O-酰基转移酶结构域-7（MBOAT7）促进透明细胞肾细胞癌的进展（CCRCC）
10. SHCBP1 Promotes Papillary Thyroid Carcinoma Carcinogenesis and Progression Through Promoting Formation of Integrin and Collagen and Maintaining Cell Stemness [O] . Houfa Geng, Mengzhe Guo, Wei Xu, 2020

机译：通过促进整联蛋白和胶原蛋白和维持细胞茎促进乳头状甲状腺癌致癌和进展。
11. Disruption of transforming growth factor-β signaling in thyroid follicular epithelial cells or intrathyroidal fibroblasts does not promote thyroid carcinogenesis [O] . Mika Shimamura, Mami Nakahara, Tomomi Kurashige, 2014

机译：转化生长因子-β信号传导在甲状腺卵泡上皮细胞或血小瘤成纤维细胞中的破坏不会促进甲状腺发生
12. Thyroid Follicular Cell Carcinogenesis: Mechanistic and Science Policy Considerations [R] . Hill, R. N. , Erdreich, L. S. , Paynter, O. E. , 1988

机译：甲状腺滤泡细胞癌变：机制和科学政策考虑因素

CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2

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