Thy1-Positive Spermatogonia Suppress the Proliferation of Spermatogonial Stem Cells by Extracellular Vesicles In Vitro

Lin Yu; Fang Qian; He Yue; Gong Xiaowen; Wang Yinjuan; Liang Ajuan; Wang Guishuan; Gong Shengnan; Wu Ji; Sun Fei

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Thy1-Positive Spermatogonia Suppress the Proliferation of Spermatogonial Stem Cells by Extracellular Vesicles In Vitro

机译：Thy1阳性精子过敏抑制了体外细胞外囊泡的精子囊泡干细胞的增殖

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The self-renewal of mammalian spermatogonial stem cells (SSCs) supports spermatogenesis to produce spermatozoa, and this is precisely controlled in a stem niche microenvironment in the seminiferous tubules. Although studies have revealed the role of the surrounding factors in SSCs, little is known about whether the division of SSCs is controlled by extracellular vesicles. Here, extracellular vesicles were found in the basal compartment of seminiferous tubules in mouse, rat, rabbit and human testes. In the mice, the testicular extracellular vesicles are secreted by spermatogonia and are taken up by SSCs. Further, the extracellular vesicles from thy1-positive spermatogonia were purified by anti-Thy1-coupled magnetic beads, which suppress their proliferation of SSCs but do not lead to the apoptosis in vitro.

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来源
《Endocrinology》 |2021年第7期|共11页
作者
Lin Yu; Fang Qian; He Yue; Gong Xiaowen; Wang Yinjuan; Liang Ajuan; Wang Guishuan; Gong Shengnan; Wu Ji; Sun Fei;
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作者单位

Shanghai Jiao Tong Univ Int Peace Matern &

Child Hlth Hosp Sch Med Inst Embryofetal Original;

Shanghai Jiao Tong Univ BioX Inst Key Lab Genet Dev &

Neuropsychiat Disorders Shanghai 200240;

Shanghai Jiao Tong Univ Int Peace Matern &

Child Hlth Hosp Sch Med Inst Embryofetal Original;

Shanghai Jiao Tong Univ BioX Inst Key Lab Genet Dev &

Neuropsychiat Disorders Shanghai 200240;

Shanghai Jiao Tong Univ BioX Inst Key Lab Genet Dev &

Neuropsychiat Disorders Shanghai 200240;

Tongji Univ Tongji Hosp Ctr Reprod Med Dept Gynecol &

Obstet Sch Med Shanghai 200065 Peoples R;

Nantong Univ Med Sch Inst Reprod Med Nantong 226001 Peoples R China;

Nantong Univ Med Sch Inst Reprod Med Nantong 226001 Peoples R China;

Shanghai Jiao Tong Univ BioX Inst Key Lab Genet Dev &

Neuropsychiat Disorders Shanghai 200240;

Shanghai Jiao Tong Univ Int Peace Matern &

Child Hlth Hosp Sch Med Inst Embryofetal Original;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
testicular extracellular vesicles; spermatogonial stem cell; proliferation;

机译：睾丸细胞外囊;精术干细胞;增殖;

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1. Histone deacetylase inhibitors attenuate P-algA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro [J] . Qin DAI, Jian LIU, Yun-lei DU, 中国药理学报：英文版 . 2016,第002期
2. Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro [J] . Juan He, Ya-Li Jiang, Yan Wang, 中华医学杂志（英文版） . 2020,第007期
3. Dahuang Zhechong Pill （大黄庶虫丸） Containing Serum Inhibited Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cells Proliferation by Inducing G1 Arrest Partly via Suppressing Protein Kinase C α-Extracellular Regulated Kinase 1/2 Signaling Pathway [J] . 刘娜, 刘俊田, 姬媛媛, 中国结合医学杂志：英文版 . 2012,第005期
4. Human spermatogonial stem cells display limited proliferation in vitro under mouse spermatogonial stem cell culture conditions [J] . Medrano Jose V., Rombaut Charlotte, Simon Carlos, Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society . 2016,第6期

机译：人精原干细胞在小鼠精原干细胞培养条件下体外显示有限的增殖
5. Extracellular vesicles from human umbilical cord mesenchymal stem cells treated with siRNA against ELFN1-AS1 suppress colon adenocarcinoma proliferation and migration [J] . Liyang Dong, Xuefeng Wang, Chaoming Mao, American Journal of Translational Research . 2019,第11期

机译：来自人脐带间充质干细胞的细胞外囊，用siRNA对抗ELFN1-AS1抑制结肠腺癌增殖和迁移
6. MicroRNA-183-5p Increases with Age in Bone-Derived Extracellular Vesicles, Suppresses Bone Marrow Stromal (Stem) Cell Proliferation, and Induces Stem Cell Senescence [J] . Davis Colleen, Dukes Amy, Drewry Michelle, Tissue engineering, Part A . 2017,第21a22期

机译：microRNA-183-5P随着骨髓细胞外囊中的年龄而增加，抑制骨髓基质（茎）细胞增殖，并诱导干细胞衰老
7. Extracellular matrix proteins regulate Adipose Derived Mesenchymal Stem Cells and Amniotk Fluid Stem Cells attachment and proliferation: utility for tissue and organ regeneration [C] . Anna Bajek, Joanna Olkowska, Natalia Gurtowska, European conference on biomaterials . 2014

机译：细胞外基质蛋白调节脂肪来源的间充质干细胞和羊膜液干细胞的附着和增殖：用于组织和器官再生
8. Retinoic acid receptor alpha in germ cells is important for mitosis of spermatogonia, spermatogonial differentiation and meiosis. [D] . Law, Sze Ming. 2013

机译：生殖细胞中的维甲酸受体α对于精原细胞的有丝分裂，精原细胞的分化和减数分裂很重要。
9. Extracellular vesicles from human umbilical cord mesenchymal stem cells treated with siRNA against ELFN1-AS1 suppress colon adenocarcinoma proliferation and migration [O] . Liyang Dong, Chao Ding, Tingting Zheng, 2019

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10. Pathway Analysis of Micrornas from Mesenchymal Stem Cell Derived Extracellular Vesicles (MSC-EV) as Compared to Lung Fibroblasts Derived Extracellular Vesicles (LFB-EV) Show Differentially Expression of Pathways That Modulate Inflammation and Cell Proliferation in an Experimental Model of Neonatal Lung Injury [O] . C. Chetty, R.K. Braun, T.E. Schmitt, 2020

机译：与肺成纤维细胞衍生的细胞外囊泡（LFB-EV）相比，来自间充质干细胞衍生细胞外囊泡（MSC-EV）的途径分析显示调节新生儿肺损伤实验模型中调节炎症和细胞增殖的差异表达的差异表达
11. Age at Which the Long-Cycling Spermatogonial Stem-Cell Population Is Established in the Mouse [R] . Oakberg, E. F. 1981

机译：在小鼠中建立长循环精原干细胞群的年龄

Thy1-Positive Spermatogonia Suppress the Proliferation of Spermatogonial Stem Cells by Extracellular Vesicles In Vitro

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