...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Effect of dimethyl fumarate on gray and white matter pathology in subjects with relapsing multiple sclerosis: a longitudinal study
【24h】

Effect of dimethyl fumarate on gray and white matter pathology in subjects with relapsing multiple sclerosis: a longitudinal study

机译：富马酸二甲酯对复发多发性硬化症灰白质病理学的影响：纵向研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and purpose Dimethyl fumarate (DMF) is an oral treatment for relapsing‐remitting multiple sclerosis (MS) with anti‐inflammatory and possible neuroprotective properties. Its effect on white matter and gray matter pathology is still not fully understood. The aim of the study was to characterize the effect of DMF on normal‐appearing white matter (NAWM) and thalamic pathology longitudinally. Methods In this observational, longitudinal, 24‐month magnetic resonance imaging study, 75 patients with relapsing‐remitting MS treated with DMF and 40 age‐ and sex‐matched healthy individuals were enrolled. Regional diffusion tensor imaging metrics and tract‐based spatial statistics analyses were used to assess differences between groups. Mean diffusivity, axial diffusivity, radial diffusivity and fractional anisotropy were measured in the thalamus and NAWM. Baseline differences and changes over time were evaluated within and between study groups. Results At baseline, patients with MS showed significantly increased diffusivity and decreased fractional anisotropy in the thalamus ( P? ?0.001 for mean diffusivity, axial diffusivity and radial diffusivity) and NAWM (all P ??0.016) compared with healthy individuals. No significant within‐group difference was found in diffusion tensor imaging measures over 24?months in either group. Healthy individuals showed a significantly greater rate of increased diffusivity parameters in the thalamus and NAWM compared with patients with MS, over 24?months ( P ??0.05). Conclusions The lack of changes in diffusion tensor imaging metrics in patients with MS over 24?months possibly indicates a neuroprotective role of DMF. These findings provide additional evidence of the beneficial effect of DMF on MS‐related pathology.
机译：None

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号