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首页> 外文期刊>European Journal of Histochemistry >IncRNA MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cell lines by targeting miR-519e-5p/YWHAH
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IncRNA MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cell lines by targeting miR-519e-5p/YWHAH

机译：Incrna mapkapk5-AS1通过靶向MIR-519E-5P / YWHAH来促进甲状腺癌细胞系的增殖和迁移

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摘要

Thyroid cancer is a common malignant tumour of the endocrine system and ranks ninth in cancer incidence worldwide. An extensive body of evidence has demonstrated that lncRNAs play a critical role in the progression of thyroid cancer. The lncRNA MAPKAPK5-AS1 has been reported to be abnormally expressed and to play a role in the development of various human cancers. However, MAPKAPK5-AS1's potential role in thyroid cancer progression remains unknown. The objective of our study was to explore the role and mechanism of MAPKAPK5-AS1 in thyroid cancer cells and provide a potential target for its biological diagnosis and treatment. We transfected sh-MAPKAPK5-AS1 and sh-NC into BCPAP and TPC-1 cells for loss-of-function assays. Results of RT-qPCR analysis demonstrated that MAPKAPK5-AS1 was more highly expressed in thyroid cancer cells compared to normal cells. Functional assays demonstrated that interfering with the expression of MAPKAPK5-AS1 notably repressed proliferation and invasion and accelerated apoptosis of BCPAP and TPC-1 cells. Mechanistically, we found that miR-519e-5p was negatively regulated by MAPKAPK5-AS1 and that tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta (YWHAH) was a target of miR-519e-5p. Additionally, rescue assays demonstrated that downregulation of MAPKAPK5-AS1 expression inhibited cell proliferation, migration, and invasion and promoted apoptosis by sponging miR-519e-5p, thereby increasing YWHAH expression. Ultimately, our study revealed that MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cells by targeting the miR-519e-5p/YWHAH axis, which provides novel insight into the development and progression of thyroid cancer.
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  • 作者

    Zhou Yan; Liu Shanshan; Luo Yan; Zhang Meiying; Jiang Xueling; Xiong Yan;

  • 作者单位

    Nanchang Univ Dept Endocrinol &

    Metab Affiliated Hosp 2 Nanchang 330006 Jiangxi Peoples R China;

    Nanchang Univ Dept Endocrinol &

    Metab Affiliated Hosp 2 Nanchang 330006 Jiangxi Peoples R China;

    Nanchang Univ Dept Endocrinol &

    Metab Affiliated Hosp 2 Nanchang 330006 Jiangxi Peoples R China;

    Nanchang Univ Dept Endocrinol &

    Metab Affiliated Hosp 2 Nanchang 330006 Jiangxi Peoples R China;

    Nanchang Univ Dept Endocrinol &

    Metab Affiliated Hosp 2 Nanchang 330006 Jiangxi Peoples R China;

    Nanchang Univ Dept Endocrinol &

    Metab Affiliated Hosp 2 Nanchang 330006 Jiangxi Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 组织学;
  • 关键词

    IncRNA MAPKAPK5-AS1; MiR-519e-5p; YWHAH; thyroid cancer cell;

    机译：Incrna mapkapk5-AS1;MIR-519E-5P;YWHAH;甲状腺癌细胞;

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