lncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway

Li Hu; Zeng Zheng; Yang Xiang; Chen Ye; He Lei; Wan Ting

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lncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway

机译：LNCRNA GCLNC1可以通过调节P53信号通路有助于卵巢癌的进展

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Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA (lncRNA) GClnc1 related to p53 signaling pathway in OC. The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues. Next, we found that lncRNA GClnc1 inhibited p53. In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. Subsequently, p53 silencing obligated the effect of lncRNA GCln1 knock down on cell proliferation and migration. To sum up, lncRNA GClncl1 contributes to the progression of OC by regulating p53 signaling pathway. Meanwhile, our findings also suggested that lncRNA GClnc1 may serve as a novel therapeutic target for OC patients.

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来源
《European Journal of Histochemistry》 |2020年第4期|共7页
作者
Li Hu; Zeng Zheng; Yang Xiang; Chen Ye; He Lei; Wan Ting;
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作者单位

Panyu Cent Hosp Dept Gynecol Guangzhou Peoples R China;

Sun Yat Sen Univ Affiliated Hosp 3 Dept Gynecol Guangzhou Peoples R China;

Panyu Cent Hosp Dept Gynecol Guangzhou Peoples R China;

Panyu Cent Hosp Dept Gynecol Guangzhou Peoples R China;

Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangzhou Peoples R China;

Sun Yat Sen Univ Canc Ctr State Key Lab Oncol South China Collaborat Innovat Ctr Canc Med Guangzhou Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类组织学;
关键词
lncRNA GClnc1; p53; ovarian cancer; target therapy;

机译：lncrana gclnc1;p53;卵巢癌;目标治疗;

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2. N-glycosylation at Asn residues 554 and 566 of E-cadherin affects cell cycle progression through extracellular signal-regulated protein kinase signaling pathway [J] . Hongbo Zhao, Xiliang Zha, Lidong Sun, 生物化学与生物物理学报：英文版 . 2008,第002期
3. LncRNA PVT1 promotes ovarian cancer progression by silencing miR-214 [J] . Ying Chen, Hui Du, Lewen Bao, 癌症生物学与医学（英文版） . 2018,第003期
4. LncRNA PVT1 promotes ovarian cancer progression by silencing miR-214 [J] . Ying Chen, Hui Du, Lewen Bao, 癌症生物学与医学：英文版 . 2018,第03)期
5. LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway [J] . Hu Li, Zheng Zeng, Xiang Yang, European Journal of Histochemistry . 2020,第4期

机译：LNCRNA GCLNC1可以通过调节P53信号通路有助于卵巢癌的进展
6. Long non-coding RNA GClnc1 promotes progression of colorectal cancer by inhibiting p53 signaling pathway [J] . Y.-X. Dong, Z.-G. Pang, J.-C. Zhang, European review for medical and pharmacological sciences. . 2019,第13期

机译：长非编码RNA GClnc1通过抑制p53信号通路促进大肠癌的进展
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机译：LNCRNA-LOM11928316通过调节PI3K-AKT-MTOR信号通路有助于胃癌进展
8. LncRNA GAS5 Inhibits Progression of Colorectal Cancer by Regulating M1/M2 Macrophages Polarization [C] . Linyu Tang, Quanpeng Li, Xianxiu Ge, International Symposium on the Frontiers of Biotechnology and Bioengineering . 2019

机译：通过调节M1 / M2巨噬细胞极化，LNCRNA Gas5抑制结肠直肠癌的进展
9. Association of glucose-regulated protein 78 (GRP78) with ovarian cancer development and progression. [D] . Alongkronrusmee, Doungkamol. 2013

机译：葡萄糖调节蛋白78（GRP78）与卵巢癌发生发展的关系。
10. LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway [O] . Hu Li, Zheng Zeng, Xiang Yang, 2020

机译：LNCRNA GCLNC1可以通过调节P53信号通路有助于卵巢癌的进展
11. LncRNA‐LOC101928316 contributes to gastric cancer progression through regulating PI3K‐Akt‐mTOR signaling pathway [O] . Chengyun Li, Geyu Liang, Sheng Yang, 2019

机译：LNCRNA-LOM11928316通过调节PI3K-AKT-MTOR信号通路有助于胃癌进展
12. Developing Inhibitors of Ovarian Cancer Progression by Targeted Disruption of the Gamma-Synuclein Activated Migratory and Survival Signaling Pathways [R] . Godwin, A. 2007

机译：通过有针对性地破坏γ-突触核蛋白激活的迁移和存活信号通路来开发卵巢癌进展的抑制剂

lncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway

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