Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions

Penteado Leticia de Aquino; Dejani Naiara Naiana; Verdan Felipe Fortino; Orlando Allan Botinhon; Nino Victoria Eugenia; Dias Fernanda De Nuzzi; Guerta Salina Ana Carolina; Medeiros Alexandra Ivo

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Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions

机译：效力细胞增收在树突细胞成熟和迁移中的独特作用，无菌或传染病

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Efferocytosis, or clearance of apoptotic cells (ACs), by dendritic cells (DCs) leads to immune response suppression and tolerance to self-antigens. However, efferocytosis of infected apoptotic cells (IACs) leads to the production of a mixed pro- and anti-inflammatory cytokine milieu. We examined the DC phenotype and ability to migrate after phagocytosis of ACs or IACs and observed higher levels of CD86 and CCR7 expression in DCs, as well as enhanced migration capacity following efferocytosis of IACs. Interestingly, higher levels of interleukin-1, interleukin-10 and prostaglandin E-2 (PGE(2)) were also produced in this context. Blockage of IAC recognition led to an impaired maturation profile and PGE(2) production, which may have contributed to reduced CD86 and CCR7 expression and migration capacity. These data contribute to the understanding of how efferocytosis of sterile or infected cells may regulate the adaptive immune response, although the precise role of PGE(2) in this process requires further investigation.

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来源
《Immunology: An Official Journal of the British Society for Immunology》 |2017年第3期|共10页
作者
Penteado Leticia de Aquino; Dejani Naiara Naiana; Verdan Felipe Fortino; Orlando Allan Botinhon; Nino Victoria Eugenia; Dias Fernanda De Nuzzi; Guerta Salina Ana Carolina; Medeiros Alexandra Ivo;
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作者单位

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Sao Paulo Brazil;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Sao Paulo Brazil;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Sao Paulo Brazil;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Sao Paulo Brazil;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Sao Paulo Brazil;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Sao Paulo Brazil;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Sao Paulo Brazil;

Sao Paulo State Univ UNESP Dept Biol Sci Sch Pharmaceut Sci Sao Paulo Brazil;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
CCR7; dendritic cells; efferocytosis; infected apoptotic cell; prostaglandin E-2;

机译：CCR7;树突状细胞;患有细胞增多症;受感染的凋亡细胞;前列腺素E-2;

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机译：效力细胞增收在树突细胞成熟和迁移中的独特作用，无菌或传染病
7. A key role for PTP1B in dendritic cell maturation, migration, and T cell activation. [J] . Cristina Martin-Granados, Alan R Prescott, Samantha Le Sommer, Journal of molecular cell biology . 2015,第6期

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Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions

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