Cidofovir: clinical experience and future perspectives on an acyclic nucleoside phosphonate analog of cytosine in the treatment of refractory and premalignant HPV-associated anal lesions.

Coremans G; Snoeck R

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Cidofovir: clinical experience and future perspectives on an acyclic nucleoside phosphonate analog of cytosine in the treatment of refractory and premalignant HPV-associated anal lesions.

机译：Cidofovir：临床经验和未来的胞嘧啶核苷酸膦酸膦酸膦酸膦酸膦酸核苷酸，治疗难治性和预先动脉的HPV相关肛门病变。

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BACKGROUND: Cidofovir, a nucleotide analog with antiviral activity against a broad range of DNA viruses including human papilloma viruses (HPV), is available off label to clinicians. OBJECTIVE: To provide a better knowledge of pharmacology and effects when topically applied. METHODS: After reviewing the chemistry, physiology, and animal studies, an overview of clinical studies is provided. RESULTS/CONCLUSIONS: Cidofovir, as a result of its antiviral and antiproliferative activity and its ability to induce apoptosis, can offer a solution for the treatment of severe recurrent HPV-induced lesions. It can also be used to attempt to treat dysplastic lesions and as an adjuvant treatment. The long-lasting antiviral activity allows infrequent dosing. As a rule, cidofovir applied on the skin is well tolerated, even in long-term treatment. The dose-limiting nephrotoxicity of the drug is not a concern in patients with a glomerular filtration rate within the normal range. Cidofovir has clearly influenced the landscape of refractory and dysplastic anogenital condylomata acuminata and its use has increased over the last decade. However, further controlled clinical trials are needed to assess the role of cidofovir and its derivatives.

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《Expert opinion on pharmacotherapy》 |2009年第8期|共10页
作者
Coremans G; Snoeck R;
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Department of Gastroenterology University Hospital Gasthuisberg Herestraat 49 3000 Leuven;

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正文语种 eng
中图分类药学;
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入库时间 2022-08-20 18:08:28

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1. Cidofovir: clinical experience and future perspectives on an acyclic nucleoside phosphonate analog of cytosine in the treatment of refractory and premalignant HPV-associated anal lesions. [J] . Coremans G, Snoeck R Expert opinion on pharmacotherapy . 2009,第8期

机译：西多福韦：胞嘧啶无环核苷膦酸酯类似物在难治性和恶性前HPV相关肛门病变治疗中的临床经验和未来展望。
2. Cidofovir: clinical experience and future perspectives on an acyclic nucleoside phosphonate analog of cytosine in the treatment of refractory and premalignant HPV-associated anal lesions. [J] . Coremans G, Snoeck R Expert opinion on pharmacotherapy . 2009,第8期

机译：Cidofovir：临床经验和未来的胞嘧啶核苷酸膦酸膦酸膦酸膦酸膦酸核苷酸，治疗难治性和预先动脉的HPV相关肛门病变。
3. Cidofovir: clinical experience and future perspectives on an acyclic nucleoside phosphonate analog of cytosine in the treatment of refractory and premalignant HPV-associated anal lesions. [J] . Coremans G, Snoeck R Expert opinion on pharmacotherapy . 2009,第8期

机译：Cidofovir：临床经验和未来的胞嘧啶核苷酸膦酸膦酸膦酸膦酸膦酸核苷酸，治疗难治性和预先动脉的HPV相关肛门病变。
4. Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir Adefovir and Tenofovir in Treatment of DNA Virus and Retrovirus Infections [O] . Erik De Clercq 2003

机译：无环核苷膦酸酯西多福韦阿德福韦和替诺福韦在治疗DNA病毒和逆转录病毒感染中的临床潜力
5. Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections [O] . De Clercq, Erik 2003

机译：无环核苷膦酸酯西多福韦，阿德福韦和替诺福韦在治疗DNA病毒和逆转录病毒感染中的临床潜力

Cidofovir: clinical experience and future perspectives on an acyclic nucleoside phosphonate analog of cytosine in the treatment of refractory and premalignant HPV-associated anal lesions.

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