G-quadruplex stabilization in the ions and maltose transporters gene inhibit Salmonella enterica growth and virulence

Jain Neha; Mishra Subodh Kumar; Shankar Uma; Jaiswal Ankit; Sharma Tarun Kumar; Kodgire Prashant; Kumar Amit

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G-quadruplex stabilization in the ions and maltose transporters gene inhibit Salmonella enterica growth and virulence

机译：在离子和麦芽糖转运蛋白基因中抑制沙门氏菌生长和毒力

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The G-quadruplex structure is a highly conserved drug target for preventing infection of several human pathogens. We tried to explore G-quadruplex forming motifs as promising drug targets in the genome of Salmonella enterica that causes enteric fever in humans. Herein, we report three highly conserved G-quadruplex motifs (SE-PGQ-1, 2, and 3) in the genome of Salmonella enterica. Bioinformatics analysis inferred the presence of SE-PGQ-1 in the regulatory region of mgtA, SE-PGQ-2 in ORF of entA, and SE-PGQ-3 in the promoter region of malE and malK genes. The G-quadruplex forming sequences were confirmed by biophysical and biomolecular techniques. Cellular studies affirm the inhibitory effect of G-quadruplex specific ligands on Salmonella enterica growth. Further, PCR inhibition, reporter based assay, and RT-qPCR assays emphasize the biological relevance of G-quadruplexes in these genes. Thus, this study confirmed the presence of G-quadruplex motifs in Salmonella enterica and characterized them as a promising drug target.

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来源
《Genomics》 |2020年第6期|共12页
作者
Jain Neha; Mishra Subodh Kumar; Shankar Uma; Jaiswal Ankit; Sharma Tarun Kumar; Kodgire Prashant; Kumar Amit;
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作者单位

Indian Inst Technol Indore Discipline Biosci &

Biomed Engn Indore 453552 India;

Indian Inst Technol Indore Discipline Biosci &

Biomed Engn Indore 453552 India;

Indian Inst Technol Indore Discipline Biosci &

Biomed Engn Indore 453552 India;

Indian Inst Technol Indore Discipline Biosci &

Biomed Engn Indore 453552 India;

Translat Hlth Sci &

Technol Inst Faridabad 121001 Haryana India;

Indian Inst Technol Indore Discipline Biosci &

Biomed Engn Indore 453552 India;

Indian Inst Technol Indore Discipline Biosci &

Biomed Engn Indore 453552 India;

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原文格式 PDF
正文语种 eng
中图分类医学遗传学;
关键词
G-quadruplex; Multi-drug resistance; Drug targets; G-quadruplex ligand; Acridine derivatives; Salmonella enterica;

机译：g-quadruplex;多药物抗性;药物靶标;g-quadreplex配体;吖啶衍生物;沙门氏菌肠;

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机译：原位观察400 keV氙离子束在-90和30（℃）C诱导的氧化钇稳定氧化锆照射区域以外的缺陷生长

G-quadruplex stabilization in the ions and maltose transporters gene inhibit Salmonella enterica growth and virulence

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