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首页> 外文期刊>Genomics >Identification of a prognostic signature of epithelial ovarian cancer based on tumor immune microenvironment exploration
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Identification of a prognostic signature of epithelial ovarian cancer based on tumor immune microenvironment exploration

机译：基于肿瘤免疫微环境勘探的上皮性卵巢癌预后鉴定鉴定

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摘要

This study aims to develop an immune-related genes (IRGs) prognostic signature to stratify the epithelial ovarian cancer (EOC) patients. We identified 332 up- and 154 down-regulated EOC-specific IRGs. As a result, candidate IRGs were idendified to construct prognostic models respectivy for overall survial and progression-free survival. The risk score was validated as a risk factor for prognosis and was used to built a combined nomogram. According to the IRG-related prognostic model, EOC patients were divided into high- and low-risk group and were further explored their association with tumor immune microenvironment (TME). CIBERSORT algorithm showed higher macrophages M1 cell, T cells follicular helper cell and plasma cells infiltrating levels in the low-risk group. In addition, the low-risk group was found with higher immunophenoscore and distinct mutation signatures compared with the high-risk group. These findings may shed light on the development of novel immune biomarkers and target therapy of EOC.
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  • 来源
    《Genomics》 |2020年第6期|共15页
  • 作者

    Liu Jinhui; Meng Huangyang; Nie Sipei; Sun Ying; Jiang Pinping; Li Siyue; Yang Jing; Sun Rui; Cheng Wenjun;

  • 作者单位

    Nanjing Med Univ Affiliated Hosp 1 Dept Gynecol 300 Guangzhou Rd Nanjing 210029 Jiangsu;

    Nanjing Med Univ Affiliated Hosp 1 Dept Gynecol 300 Guangzhou Rd Nanjing 210029 Jiangsu;

    Nanjing Med Univ Affiliated Hosp 1 Dept Gynecol 300 Guangzhou Rd Nanjing 210029 Jiangsu;

    Nanjing Med Univ Affiliated Hosp 1 Dept Gynecol 300 Guangzhou Rd Nanjing 210029 Jiangsu;

    Nanjing Med Univ Affiliated Hosp 1 Dept Gynecol 300 Guangzhou Rd Nanjing 210029 Jiangsu;

    Nanjing Med Univ Affiliated Hosp 1 Dept Gynecol 300 Guangzhou Rd Nanjing 210029 Jiangsu;

    Nanjing Med Univ Affiliated Hosp 1 Dept Gynecol 300 Guangzhou Rd Nanjing 210029 Jiangsu;

    Nanjing Med Univ Affiliated Hosp 1 Dept Gynecol 300 Guangzhou Rd Nanjing 210029 Jiangsu;

    Nanjing Med Univ Affiliated Hosp 1 Dept Gynecol 300 Guangzhou Rd Nanjing 210029 Jiangsu;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学遗传学;
  • 关键词

    Immune signature; Epithelial ovarian cancer; Prognosis; Immune checkpoint inhibitor response; Tumor immune microenvironment;

    机译：免疫签名;上皮卵巢癌;预后;免疫检查点抑制剂反应;肿瘤免疫微环境;

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