Carbonic anhydrase activators

Supuran Claudiu T.

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Carbonic anhydrase activators

机译：碳酸酐酶激活剂

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Mammalian carbonic anhydrases (CAs; EC 4.2.1.1) of which 16 isoforms are known, are involved in important physiological functions. Their inhibition is exploited pharmacologically for the treatment of many diseases (glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, etc.) but the activators were less investigated till recently. A review on the CA activation is presented, with the activation mechanism, drug design approaches of activators and comparison of the various isoforms activation profiles being discussed. Some CAs, which are abundant in the brain, were recently demonstrated to be activatable by drug-like compounds, affording the possibility to design agents that enhance cognition, with potential therapeutic applications in aging and neurodegenerative diseases as well as tissue engineering.

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《Future medicinal chemistry》 |2018年第5期|共14页
作者
Supuran Claudiu T.;
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作者单位

Univ Firenze Sez Sci Farmaceut &

Nutraceut Dipartimento Neurofarba Via U Schiff 6 I-50019;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
activator; amine; amino acid; carbonic anhydrase; cognition enhancement; proton transfer;

机译：活化剂;胺;氨基酸;碳酸酐酶;认知增强;质子转移;

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专利

1. Role of Carbonic Anhydrase as an Activator in Carbonate Rock Dissolution and Its Implication for Atmospheric CO2 Sink [J] . 刘再华地质学报（英文版） . 2001,第003期
2. Biosynthesized Gold/Activated Carbon Catalyst for Aerobic Glucose Oxidation: Influence of Acid Treatment on Activated Carbon [J] . Fenfen Lu, Yan Xu, Xia Jiang, 中国化学（英文版） . 2017,第005期
3. High-capacity porous carbons prepared by KOH activation of activated carbon for supercapacitors [J] . Yong Xiao, Chao Long, Ming-Tao Zheng, 中国化学快报（英文版） . 2014,第006期
4. Methane Adsorption Study Using Activated Carbon Fiber and Coal Based Activated Carbon [J] . Guo Deyong, Li Fei, Liu Wenge 中国炼油与石油化工（英文版） . 2013,第004期
5. Catalytic Effect of Activated Carbon and Activated Carbon Fiber in Non-Equilibrium Plasma-Based Water Treatment [J] . 张延宗, 郑经堂, 曲险峰, 等离子体科学和技术：英文版 . 2008,第003期
6. Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators [J] . Alessio Nocentini, Doretta Cuffaro, Lidia Ciccone, Journal of enzyme inhibition and medicinal chemistry. . 2021,第1期

机译：氨基醇肟醚从人脑中激活碳酸酐酶：朝向人碳酸酐酶VII选择性活化剂
7. Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from Malassezia globosa with amines and amino acids [J] . Vullo Daniela, Del Prete Sonia, Capasso Clemente, Bioorganic and Medicinal Chemistry Letters . 2016,第5期

机译：碳酸酐酶激活剂：用胺和氨基酸激活球形小球藻的β-碳酸酐酶
8. Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids. [J] . Innocenti A, Hall RA, Scozzafava Bioorganic and medicinal chemistry . 2010,第3期

机译：碳酸酐酶激活剂：用胺和氨基酸激活病原真菌白色念珠菌和新隐球菌的β-碳酸酐酶。
9. Role of Carbonic Anhydrase as an Activator in Carbonate Rock Dissolution and Its Implication for Atmospheric CO<,2> Sink [C] . LIU Zaihua Acta Geologica Sinica : Karst China 2001: Abstracts with programs . 2001

机译：碳酸酐酶作为活化剂在碳酸盐岩溶解中的作用及其对大气CO 2，Sink的影响
10. (I) Zinc complexes as synthetic analogues for carbonic anhydrase and as catalysts for hydrogen production and carbon dioxide functionalization (II) Application of lithium silylamides in the synthesis of transition metal isocyanide compounds from their car [D] . Sattler, Wesley. 2012

机译：（I）锌配合物，可作为碳酸酐酶的合成类似物，并用作制氢和二氧化碳功能化的催化剂（II）甲硅烷基锂在其汽车合成过渡金属异氰化物中的应用
11. Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators [O] . Alessio Nocentini, Doretta Cuffaro, Lidia Ciccone, 2021

机译：氨基醇肟醚从人脑中激活碳酸酐酶：朝向人碳酸酐酶VII选择性活化剂
12. Structure and function of carbonic anhydrases Imidazole binding to human carbonic anhydrase B and the mechanism of action of carbonic anhydrases [O] . Kannan K.K., Petef M., Fridborg K., 1977

机译：碳酸酐酶的结构和功能咪唑与人碳酸酐酶B的结合以及碳酸酐酶的作用机理
13. Investigation of Enhancement of Carbon Dioxide Absorption by Amines with the Enzyme Carbonic Anhydrase. [R] . Allen, J. P. 1966

机译：胺类碳酸酐酶增强胺类吸收二氧化碳的研究。

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