Molecular and evolutionary processes generating variation in gene expression.

Mark S Hill; Pétra Vande Zande; Patricia J Wittkopp

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Molecular and evolutionary processes generating variation in gene expression.

机译：基因表达的变化的分子和进化过程。

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Heritable variation in gene expression is common within and between species. This variation arises from mutations that alter the form or function of molecular gene regulatory networks that are then filtered by natural selection. High-throughput methods for introducing mutations and characterizing their cis- and trans-regulatory effects on gene expression (particularly, transcription) are revealing how different molecular mechanisms generate regulatory variation, and studies comparing these mutational effects with variation seen in the wild are teasing apart the role of neutral and non-neutral evolutionary processes. This integration of molecular and evolutionary biology allows us to understand how the variation in gene expression we see today came to be and to predict how it is most likely to evolve in the future.

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《Nature reviews. Genetics》 |2021年第4期|共13页
作者
Mark S Hill; Pétra Vande Zande; Patricia J Wittkopp;
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Department of Ecology and Evolutionary Biology University of Michigan;

Department of Molecular Cellular and Developmental Biology University of Michigan;

Department of Ecology and Evolutionary Biology University of Michigan;

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正文语种 eng
中图分类普通生物学;
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2. From SNPs to function: the effect of sequence variation on gene expression. Focus on "A survey of genetic and epigenetic variation affecting human gene expression" [J] . Michael Olivier Physiological genomics . 2004,第0期

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3. Molecular Mechanisms and Evolutionary Processes Contributing to Accelerated Divergence of Gene Expression on the Drosophila X Chromosome [J] . Coolon Joseph D., Stevenson Kraig R., McManus C. Joel, Molecular biology and evolution . 2015,第10期

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8. Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. [O] . Ozcan, S, Dover, J, Rosenwald, A G, 1996

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Molecular and evolutionary processes generating variation in gene expression.

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