Mutation-selection balance and compensatory mechanisms in tumour evolution.

Erez Persi; Yuri I Wolf; David Horn; Eytan Ruppin; Francesca Demichelis; Robert A Gatenby; Robert J Gillies; Eugene V Koonin

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Mutation-selection balance and compensatory mechanisms in tumour evolution.

机译：肿瘤进化中的突变选择平衡与补偿机制。

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Intratumour heterogeneity and phenotypic plasticity, sustained by a range of somatic aberrations, as well as epigenetic and metabolic adaptations, are the principal mechanisms that enable cancers to resist treatment and survive under environmental stress. A comprehensive picture of the interplay between different somatic aberrations, from point mutations to whole-genome duplications, in tumour initiation and progression is lacking. We posit that different genomic aberrations generally exhibit a temporal order, shaped by a balance between the levels of mutations and selective pressures. Repeat instability emerges first, followed by larger aberrations, with compensatory effects leading to robust tumour fitness maintained throughout the tumour progression. A better understanding of the interplay between genetic aberrations, the microenvironment, and epigenetic and metabolic cellular states is essential for early detection and prevention of cancer as well as development of efficient therapeutic strategies.

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《Nature reviews. Genetics》 |2021年第4期|共12页
作者
Erez Persi; Yuri I Wolf; David Horn; Eytan Ruppin; Francesca Demichelis; Robert A Gatenby; Robert J Gillies; Eugene V Koonin;
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作者单位

National Center for Biotechnology Information National Library of Medicine National Institutes of;

National Center for Biotechnology Information National Library of Medicine National Institutes of;

School of Physics and Astronomy Raymond &

Beverly Sackler Faculty of Exact Sciences Tel-Aviv;

Cancer Data Science Lab National Cancer Institute National Institutes of Health;

Department for Cellular Computational and Integrative Biology University of Trento;

Integrated Mathematical Oncology H. Lee Moffitt Cancer Center and Research Institute;

Department of Cancer Physiology H. Lee Moffitt Cancer Center and Research Institute;

National Center for Biotechnology Information National Library of Medicine National Institutes of;

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正文语种 eng
中图分类普通生物学;
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Mutation-selection balance and compensatory mechanisms in tumour evolution.

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