Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection

Fernandez Estefania; Dejnirattisai Wanwisa; Cao Bin; Scheaffer Suzanne M.; Supasa Piyada; Wongwiwat Wiyada; Esakky Prabagaran; Drury Andrea; Mongkolsapaya Juthathip; Moley Kelle H.; Mysorekar Indira U.; Screaton Gavin R.; Diamond Michael S.

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Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection

机译：登革热病毒E-Dimer表位的人抗体对Zika病毒感染具有治疗活动

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The Zika virus (ZIKV) epidemic has resulted in congenital abnormalities in fetuses and neonates. Although some cross-reactive dengue virus (DENV)-specific antibodies can enhance ZIKV infection in mice, those recognizing the DENV E-dimer epitope (EDE) can neutralize ZIKV infection in cell culture. We evaluated the therapeutic activity of human monoclonal antibodies to DENV EDE for their ability to control ZIKV infection in the brains, testes, placentas, and fetuses of mice. A single dose of the EDE1-B10 antibody given 3 d after ZIKV infection protected against lethality, reduced ZIKV levels in brains and testes, and preserved sperm counts. In pregnant mice, wild-type or engineered LALA variants of EDE1-B10, which cannot engage Fc gamma receptors, diminished ZIKV burden in maternal and fetal tissues, and protected against fetal demise. Because neutralizing antibodies to EDE have therapeutic potential against ZIKV, in addition to their established inhibitory effects against DENV, it may be possible to develop therapies that control disease caused by both viruses.

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《Nature immunology》 |2017年第11期|共9页
作者
Fernandez Estefania; Dejnirattisai Wanwisa; Cao Bin; Scheaffer Suzanne M.; Supasa Piyada; Wongwiwat Wiyada; Esakky Prabagaran; Drury Andrea; Mongkolsapaya Juthathip; Moley Kelle H.; Mysorekar Indira U.; Screaton Gavin R.; Diamond Michael S.;
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作者单位

Washington Univ Sch Med Dept Pathol &

Immunol St Louis MO 63110 USA;

Imperial Coll Dept Med Div Immunol &

Inflammat Hammersmith Campus London England;

Washington Univ Sch Med Dept Obstet &

Gynecol St Louis MO 63110 USA;

Washington Univ Sch Med Dept Obstet &

Gynecol St Louis MO 63110 USA;

Imperial Coll Dept Med Div Immunol &

Inflammat Hammersmith Campus London England;

Imperial Coll Dept Med Div Immunol &

Inflammat Hammersmith Campus London England;

Washington Univ Sch Med Dept Obstet &

Gynecol St Louis MO 63110 USA;

Washington Univ Sch Med Dept Obstet &

Gynecol St Louis MO 63110 USA;

Imperial Coll Dept Med Div Immunol &

Inflammat Hammersmith Campus London England;

Washington Univ Sch Med Dept Obstet &

Gynecol St Louis MO 63110 USA;

Washington Univ Sch Med Dept Pathol &

Immunol St Louis MO 63110 USA;

Imperial Coll Dept Med Div Immunol &

Inflammat Hammersmith Campus London England;

Washington Univ Sch Med Dept Pathol &

Immunol St Louis MO 63110 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
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1. Plasmid DNA encoding neutralizing human monoclonal antibody without enhancing activity protects against dengue virus infection in mice [J] . Surachet Benjathummarak, Atsushi Yamanaka, Thanyaluk Krasae, 亚太热带医药杂志（英文版） . 2021,第007期
2. Dengue virus infections and anti-dengue virus activities of Andrographis paniculata [J] . Mohamed Ali-Seyed, Kavitha Vijayaraghavan 亚太热带医药杂志（英文版） . 2020,第002期
3. Advances in the research and development of therapeutic antibodies against the Zika virus [J] . Shibo Jiang, Lanying Du 细胞与分子免疫学：英文版 . 2019,第001期
4. Antibodies induced by multi-epitope vaccine showed inhibitory activity against heterologous influenza A virus (H3N2) [J] . DING Jian, WU Fan, WEI Wei, 自然科学进展（英文版） . 2006,第001期
5. Author Correction: Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection. [J] . Nature immunology . 2020,第3期

机译：作者校正：人类抗体对登革热病毒E二聚体表位具有针对Zika病毒感染的治疗活动。
6. Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection [J] . Fernandez Estefania, Dejnirattisai Wanwisa, Cao Bin, Nature immunology . 2017,第11期

机译：登革热病毒E-Dimer表位的人抗体对Zika病毒感染具有治疗活动
7. Human Serum With High Neutralizing Antibody Titers Against Both Zika and Dengue Virus Shows Delayed In Vitro Antibody-Dependent Enhancement of Dengue Virus Infection [J] . William G Valiant, Tahaniyat Lalani, Heather C Yun, Open Forum Infectious Diseases . 2018,第7期

机译：对寨卡病毒和登革热病毒均具有高中和抗体滴度的人血清显示延迟的抗体依赖性登革热病毒感染的体外增强
8. Cellular-Level Characterization of Dengue and Zika Virus Infection Using Multiagent Simulation [C] . Andreina Alvarado, Ricardo Corrales, Maria Jose Leal, 2018 IEEE International Work Conference on Bioinspired Intelligence . 2018

机译：使用多剂模拟的登革热和寨卡病毒感染的细胞水平表征
9. Mapping of four immunodominant epitopes of dengue virus-specific human CD4(+) T cell clones and analysis of simian hemorrhagic fever virus RNAs. [D] . Zeng, Lingling. 1994

机译：登革热病毒特异性人CD4（+）T细胞克隆的四个免疫优势表位的定位和猿猴出血热病毒RNA的分析。
10. Anti-Dengue E-dimer epitope human antibodies have therapeutic activity against Zika virus infection [O] . Estefania Fernandez, Wanwisa Dejnirattisai, Bin Cao, -1

机译：抗登革热E-二聚体表位人类抗体具有抵抗寨卡病毒感染的治疗活性
11. Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection. [O] . Fernandez, E, Dejnirattisai, W, Cao, B, 2017

机译：登革热病毒E-二聚体表位的人抗体具有针对寨卡病毒感染的治疗活性。
12. Infection Enhancement of Dengue Type 2 Virus in the U-937 Human Monocyte Cell Line by Antibodies to Flavivirus Cross-Reactive Determinants. [R] . Brandt, W. E., McCown, J. M., Gentry, M. K., 1981

机译：通过黄病毒交叉反应决定因子的抗体增强登革2型病毒在U-937人单核细胞系中的感染。

Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection

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