Antiviral B cell and T cell immunity in the lungs

Chiu Christopher; Openshaw Peter J.

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Antiviral B cell and T cell immunity in the lungs

机译：肺中的抗病毒B细胞和T细胞免疫力

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Respiratory viruses are frequent causes of repeated common colds, bronchitis and pneumonia, which often occur unpredictably as epidemics and pandemics. Despite those decimating effects on health and decades of intensive research, treatments remain largely supportive. The only commonly available vaccines are against influenza virus, and even these need improvement. The lung shares some features with other mucosal sites, but preservation of its especially delicate anatomical structures necessitates a fine balance of pro- and anti-inflammatory responses; well-timed, appropriately placed and tightly regulated T cell and B cell responses are essential for protection from infection and limitation of symptoms, whereas poorly regulated inflammation contributes to tissue damage and disease. Recent advances in understanding adaptive immunity should facilitate vaccine development and reduce the global effect of respiratory viruses.

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来源
《Nature immunology》 |2015年第1期|共9页
作者
Chiu Christopher; Openshaw Peter J.;
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作者单位

Univ London Imperial Coll Sci Technol &

Med Ctr Resp Infect Natl Heart &

Lung Inst London;

Univ London Imperial Coll Sci Technol &

Med Ctr Resp Infect Natl Heart &

Lung Inst London;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
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Antiviral B cell and T cell immunity in the lungs

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