Targetable gene fusions and aberrations in genitourinary oncology

Pederzoli Filippo; Bandini Marco; Marandino Laura; Ali Siraj M.; Madison Russell; Chung Jon; Ross Jeffrey S.; Necchi Andrea

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Targetable gene fusions and aberrations in genitourinary oncology

机译：泌尿生殖肿瘤学中的可算是基因融合和畸变

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Gene fusions result from either structural chromosomal rearrangement or aberrations caused by splicing or transcriptional readthrough. The precise and distinctive presence of fusion genes in neoplastic tissues and their involvement in multiple pathways central to cancer development, growth and survival make them promising targets for personalized therapy. In genitourinary malignancies, rearrangements involving the E26 transformation-specific family of transcription factors have emerged as very frequent alterations in prostate cancer, especially theTMPRSS2-ERGfusion. In renal malignancies, Xp11 and t(6;11) translocations are hallmarks of a distinct pathological group of tumours described as microphthalmia-associated transcription factor family translocation-associated renal cell carcinomas. Novel druggable fusion events have been recognized in genitourinary malignancies, leading to the activation of several clinical trials. For instance,ALK-rearranged renal cell carcinomas have shown responses to alectinib and crizotinib. Erdafitinib has been tested for the treatment ofFGFR-rearranged bladder cancer. Other anti-fibroblast growth factor receptor 3 (FGFR3) compounds are showing promising results in the treatment of bladder cancer, including infigratinib and pemigatinib, and all are currently in clinical trials.

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来源
《Nature reviews. Urology》 |2020年第11期|共13页
作者
Pederzoli Filippo; Bandini Marco; Marandino Laura; Ali Siraj M.; Madison Russell; Chung Jon; Ross Jeffrey S.; Necchi Andrea;
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Univ Vita Salute San Raffaele IRCCS Osped San Raffaele Unit Urol Urol Res Inst URI Milan Italy;

Univ Vita Salute San Raffaele IRCCS Osped San Raffaele Unit Urol Urol Res Inst URI Milan Italy;

Fdn IRCCS Ist Nazl Tumori Milan Italy;

Fdn Med Inc Cambridge MA USA;

Fdn Med Inc Cambridge MA USA;

Fdn Med Inc Cambridge MA USA;

Fdn Med Inc Cambridge MA USA;

Fdn IRCCS Ist Nazl Tumori Milan Italy;

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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
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1. A non-viral vector for potential DMD gene therapy study by targeting a minidystrophin-GFP fusion gene into the hrDNA locus [J] . Junlin Yang, Xionghao Liu, Jiaoling Yu, 生物化学与生物物理学报：英文版 . 2009,第012期
2. A non-viral vector for potential DMD gene therapy study by targeting a minidystrophin-GFP fusion gene into the hrDNA locus [J] . Junlin Yang, Yu Liang, Jiahui Xia, 生物化学与生物物理学报：英文版 . 2009,第012期
3. Identification and characterization of novel fusion genes in prostate cancer by targeted RNA capture and next-generation sequencing [J] . Jie Yang, Yun Chen, Jingxiao Lu, 生物化学与生物物理学报：英文版 . 2018,第011期
4. Fusion genes in solid tumors:an emerging target for cancer diagnosis and treatment [J] . Brittany C. Parker, Wei Zhang 癌症（英文版） . 2013,第011期
5. Fusion Reactor and Fusion Reactor Materials— Target Fuel Depletion Fraction and Energy Gain of Inertial Confinement Fusion with D-3He Advanced Fuel [J] . DENG, Baiquan, FENG, 核工业西南物理研究院年报：英文版 . 2004,第001期
6. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group [J] . Reshmi Shalini C., Harvey Richard C., Roberts Kathryn G., Blood: The Journal of the American Society of Hematology . 2017,第25期

机译：高风险的靶向激酶基因融合 - 全部：儿童肿瘤学群体的研究
7. Identification of a Novel MAN1A1-ROS1 Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma [J] . Suehara Yoshiyuki, Kohsaka Shinji, Hayashi Takuo, Clinical Orthopaedics and Related Research . 2021,第4期

机译：通过基于mRNA的筛选筛选酪氨酸激酶基因畸变的鉴定新的MAN1A1-ROS1融合基因的患者患者患者患者患者
8. CORR Insights (R): Identification of a Novel MAN1A1-ROS1 Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma [J] . Tang Xiaodong Clinical Orthopaedics and Related Research . 2021,第4期

机译：Corr Insights（R）：通过基于mRNA的筛选筛选酪氨酸激酶基因畸变的新型MAN1A1-ROS1融合基因的鉴定，Leiomyosarcoma患者
9. Engineered Extracellular Vesicles with Synthetic Lipids via Membrane Fusion to Establish Efficient and Targeted Drug and Gene Delivery [C] . Yong Yu Jhan, David Moore, Shreedevi Arun Kumar, Society for Biomaterials annual meeting and exposition . 2018

机译：通过膜融合工程合成脂质的细胞外囊泡，以建立有效的靶向药物和基因递送
10. Characterization of genomic targets of chromosomal aberrations and an in vivo model of disrupted nonsense mediated decay. [D] . Mahowald, Grace Kao. 2011

机译：染色体畸变的基因组靶标的表征和无意义的介导的衰变的体内模型。
11. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children’s Oncology Group [O] . Shalini C. Reshmi, Richard C. Harvey, Kathryn G. Roberts, -1

机译：高危B-ALL中的可靶向激酶基因融合：儿童肿瘤学小组的一项研究
12. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children’s Oncology Group [O] . Shalini C. Reshmi, Richard C. Harvey, Kathryn G. Roberts, 2017

机译：高风险B-全部的可靶向激酶基因融合：来自儿童肿瘤学群的研究
13. Highly Specific Targeting of the TMPRSS2/ERG Fusion Gene in Prostate Cancer Using Liposomal Nanotechnology. [R] . Ozpolat, B., Ittmann, M. 2013

机译：使用脂质体纳米技术高度特异性靶向TmpRss2 / ERG融合基因在前列腺癌中的应用。

Targetable gene fusions and aberrations in genitourinary oncology

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