Anxiolytic-like effect of brominated compounds from the marine sponge Aplysina fulva on adult zebrafish (Danio rerio): Involvement of the GABAergic system

Cesario Hozana Patricia S. de F.; Silva Francisca Crislandia O.; Ferreira Maria Kueirislene A.; de Menezes Jane Eire S. A.; Santos Helcio S. dos; Nogueira Carlos E. S.; Silva Karisia S. B. de L.; Hajdu Eduardo; Silveira Edilberto R.; Pessoa Otilia Deusdenia L.

首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Anxiolytic-like effect of brominated compounds from the marine sponge Aplysina fulva on adult zebrafish (Danio rerio): Involvement of the GABAergic system

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Anxiolytic-like effect of brominated compounds from the marine sponge Aplysina fulva on adult zebrafish (Danio rerio): Involvement of the GABAergic system

机译：来自海绵的氧纤维状化合物在成人斑马鱼（Danio Rerio）上的溴化化合物的奶粉状物的疗效：加工系统的参与

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Benzodiazepines are commonly used to treat disorders of the central nervous system, including anxiety. However, due to their adverse effects, there is a continuing interest in discovering new safe and effective drugs. Marine natural products have emerged as a prolific source of bioactive nitrogenated compounds. Aiming to discover new biologically active natural compounds, the marine sponge Aplysina fulva, a nitrogen-bearing heterocyst producer, was investigated. The main isolated compounds (4, 6, and 9) were evaluated on adult zebrafish (Danio rerio). A group of fishes (n = 6) was preliminarily subjected to acute toxicity, and open field tests using 0.1, 0.5, and 1.0 mg/mL (v. o.) of those compounds was performed. The anxiolytic effect was further investigated in the light/dark assay based on the locomotor response at zebrafish. Interactions through the GABAergic system were investigated using flumazenil, a silent modulator of GABA receptors. To improve the results, a study of molecular docking using the GABAA receptor also was performed. Based on the results, the bromotyrosine derivative compounds 4, 6, and 9 exhibited anxiolytic-like effects mediated by the GABAergic system.

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来源
《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2021年第1期|共9页
作者
Cesario Hozana Patricia S. de F.; Silva Francisca Crislandia O.; Ferreira Maria Kueirislene A.; de Menezes Jane Eire S. A.; Santos Helcio S. dos; Nogueira Carlos E. S.; Silva Karisia S. B. de L.; Hajdu Eduardo; Silveira Edilberto R.; Pessoa Otilia Deusdenia L.;
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作者单位

Univ Fed Ceara Dept Organ &

Inorgan Chem Sci Ctr BR-60455760 Fortaleza CE Brazil;

Univ Estadual Ceara Lab Chem Nat Prod BR-60174903 Fortaleza CE Brazil;

Univ Estadual Ceara Lab Chem Nat Prod BR-60174903 Fortaleza CE Brazil;

Univ Estadual Ceara Lab Chem Nat Prod BR-60174903 Fortaleza CE Brazil;

Vale do Acarau Univ Lab Chem Nat Prod Synth &

Biocatalysis Organ Cpds BR-62040370 Sobral CE;

Reg Univ Cariri Dept Phys BR-63041145 Crato CE Brazil;

Univ Fed Ceara Dept Organ &

Inorgan Chem Sci Ctr BR-60455760 Fortaleza CE Brazil;

Univ Fed Rio de Janeiro Dept Invertebrates Natl Museum BR-20940040 Rio De Janeiro RJ Brazil;

Univ Fed Ceara Dept Organ &

Inorgan Chem Sci Ctr BR-60455760 Fortaleza CE Brazil;

Univ Fed Ceara Dept Organ &

Inorgan Chem Sci Ctr BR-60455760 Fortaleza CE Brazil;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Aplysina fulva; Nitrogenated compounds; Benzodiazepines; Zebrafish; Anxiolytic effect;

机译：Aplysina Fulva;氮化合物;苯并二氮杂虫;斑马鱼;抗焦虑作用;

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Anxiolytic-like effect of brominated compounds from the marine sponge Aplysina fulva on adult zebrafish (Danio rerio): Involvement of the GABAergic system

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