Minutes of PPAR-gamma agonism and neuroprotection

Kumar B. R. Prashantha; Kumar Ashwini Prem; Jose Jincy A.; Prabitha P.; Yuvaraj S.; Chipurupalli Sandhya; Jeyarani Victoria; Manisha Chennu; Banerjee Sayani; Jeyabalan Jeyaram Bharathi; Mohankumar Suresh Kumar; Dhanabal S. P.; Justin Antony

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Minutes of PPAR-gamma agonism and neuroprotection

机译：几分钟的PPAR-Gamma激动主义和神经保护作用

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Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is one of the ligand-activated transcription factors which regulates a number of central events and considered as a promising target for various neurodegenerative disease conditions. Numerous reports implicate that PPAR-gamma agonists have shown neuroprotective effects by regulating genes transcription associated with the pathogenesis of neurodegeneration. In regards, this review critically appraises the recent knowledge of PPAR-gamma receptors in neuroprotection in order to hypothesize potential neuroprotective mechanism of PPAR-gamma agonism in chronic neurological conditions. Of note, the PPAR-gamma's interaction dynamics with PPAR-gamma coactivator-1 alpha (PGC-1 alpha) has gained significant attention for neuroprotection. Likewise, a plethora of studies suggest that the PPAR-gamma pathway can be actuated by the endogenous ligands present in the CNS and thus identification and development of novel agonist for the PPAR-gamma receptor holds a vow to prevent neurodegeneration. Together, the critical insights of this review enlighten the translational possibilities of developing novel neuroprotective therapeutics targeting PPAR-gamma for various neurodegenerative disease conditions.

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来源
《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2020年第1期|共9页
作者
Kumar B. R. Prashantha; Kumar Ashwini Prem; Jose Jincy A.; Prabitha P.; Yuvaraj S.; Chipurupalli Sandhya; Jeyarani Victoria; Manisha Chennu; Banerjee Sayani; Jeyabalan Jeyaram Bharathi; Mohankumar Suresh Kumar; Dhanabal S. P.; Justin Antony;
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作者单位

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmaceut Chem Mysuru Karnataka India;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmacol Nilgiris 643001 Tamil Nadu India;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmacol Nilgiris 643001 Tamil Nadu India;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmaceut Chem Mysuru Karnataka India;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmaceut Chem Mysuru Karnataka India;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmacol Nilgiris 643001 Tamil Nadu India;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmacol Nilgiris 643001 Tamil Nadu India;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmacol Nilgiris 643001 Tamil Nadu India;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmacol Nilgiris 643001 Tamil Nadu India;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmacol Nilgiris 643001 Tamil Nadu India;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmacognosy TIFAC Core HD Nilgiris Tamil Nadu;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmacognosy TIFAC Core HD Nilgiris Tamil Nadu;

JSS Acad Higher Educ &

Res JSS Coll Pharm Dept Pharmacol Nilgiris 643001 Tamil Nadu India;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
PPAR-gamma; PGC-1 alpha signaling; Endogenous ligand; Oxidative stress; Mitochondrial biogenesis; Agonists; Neuroprotection;

机译：PPAR-Gamma;PGC-1α信号;内源性配体;氧化应激;线粒体生物发生;激动剂;神经保护作用;

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Minutes of PPAR-gamma agonism and neuroprotection

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