Lycopene - A pleiotropic neuroprotective nutraceutical: Deciphering its therapeutic potentials in broad spectrum neurological disorders

Paul Rajib; Mazumder Muhammed Khairujjaman; Nath Joyobrato; Deb Satarupa; Paul Satinath; Bhattacharya Pallab; Borah Anupom

首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Lycopene - A pleiotropic neuroprotective nutraceutical: Deciphering its therapeutic potentials in broad spectrum neurological disorders

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Lycopene - A pleiotropic neuroprotective nutraceutical: Deciphering its therapeutic potentials in broad spectrum neurological disorders

机译：番茄红素 - 一种抗脂性神经保护营养保健品：在广谱神经系统障碍中解读其治疗潜力

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Lycopene is a naturally occurring carotenoid found abundantly in red fruits and vegetables. Myriads of literature documented potential health benefits of lycopene, owing to its sublime capacity of suppressing oxidative stress, inflammation, and modulation of various cell survival pathways. Due to its lipophilic nature, lycopene can reach brain adequately by traversing the blood-brain barrier thereby extending it's promising therapeutic benefits in neurological disorders. Lycopene efficiently assists in restoring the characteristic behavioural and pathophysiological changes associated with neurodegenerative disorders, epileptic conditions, aging, subarachnoid hemorrhage, spinal cord injury, and neuropathy. The detrimental impacts of environmental neurotoxins on brain and neuropathological consequences of consumption of high-lipid diet can also be mitigated by lycopene. Apart from its high antioxidant potency, lycopene confers neuroprotection by preventing proteinopathies, neuroinflammation, apoptosis, cerebral edema, and synaptic dysfunction. This review provides a lucid idea on the potential multi-faceted benefits of lycopene in disorders of the central nervous system and elucidates the molecular mechanisms and pathways of its action.

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来源
《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2020年第1期|共16页
作者
Paul Rajib; Mazumder Muhammed Khairujjaman; Nath Joyobrato; Deb Satarupa; Paul Satinath; Bhattacharya Pallab; Borah Anupom;
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作者单位

Pandit Deendayal Upadhyaya Adarsha Mahavidyalaya Dept Zool Karimganj 788723 Assam India;

Dhemaji Coll Dept Zool Dhemaji 787057 Assam India;

Cachar Coll Dept Zool Silchar 788001 Assam India;

Assam Univ Dept Life Sci &

Bioinfomat Cellular &

Mol Neurobiol Lab Silchar 788011 Assam India;

Pandit Deendayal Upadhyaya Adarsha Mahavidyalaya Dept Zool Karimganj 788723 Assam India;

Natl Inst Pharmaceut Educ &

Res NIPER Ahmedabad Dept Pharmacol &

Toxicol Gandhinagar 382355;

Assam Univ Dept Life Sci &

Bioinfomat Cellular &

Mol Neurobiol Lab Silchar 788011 Assam India;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Neurodegenerative disorders; Environmental toxins; Antioxidant; Inflammation; Apoptosis;

机译：神经变性障碍;环境毒素;抗氧化剂;炎症;细胞凋亡;

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机译：α-亚麻酸，具有多效性的营养保健品，其靶向内源性神经保护途径以防止有机磷酸盐神经剂诱导的神经病理学

Lycopene - A pleiotropic neuroprotective nutraceutical: Deciphering its therapeutic potentials in broad spectrum neurological disorders

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