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Cell Biology of Astrocyte-Synapse Interactions

机译：星形胶质细胞突触相互作用的细胞生物学

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摘要

Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of brain development and physiology through dynamic and often bidirectional interactions with neuronal synapses. Despite the clear importance of astrocytes for the establishment and maintenance of proper synaptic connectivity, our understanding of their role in brain function is still in its infancy. We propose that this is at least in part due to large gaps in our knowledge of the cell biology of astrocytes and the mechanisms they use to interact with synapses. In this review, we summarize some of the seminal findings that yield important insight into the cellular and molecular basis of astrocyte-neuron communication, focusing on the role of astrocytes in the development and remodeling of synapses. Furthermore, we pose some pressing questions that need to be addressed to advance our mechanistic understanding of the role of astrocytes in regulating synaptic development. Allen and Eroglu review the current state of knowledge on the cell biology of astrocyte-synapse interactions and pose some pressing questions that need to be addressed to advance our understanding of the role of astrocytes in brain function.
机译：None

著录项

  • 来源
    《Neuron》 |2017年第3期|共12页
  • 作者

    Nicola J. Allen; Cagla Eroglu;

  • 作者单位

    Molecular Neurobiology Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines;

    Department of Cell Biology Duke University Medical Center Durham NC 27710 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

    astrocyte; synapse; glia;

    机译：星形胶质细胞;Synapse;Glia;

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