Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons

Mandelblat-Cerf Yael; Kim Angela; Burgess Christian R.; Subramanian Siva; Tannous Bakhos A.; Lowell Bradford B.; Andermann Mark L.

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Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons

机译：对VasoPressin神经元的未来渗透挑战的双向预期

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Ingestion of water and food are major hypo-and hyperosmotic challenges. To protect the body from osmotic stress, posterior pituitary-projecting, vasopressin- secreting neurons (VPpp neurons) counter osmotic perturbations by altering their release of vasopressin, which controls renal water excretion. Vasopressin levels begin to fall within minutes of water consumption, even prior to changes in blood osmolality. To ascertain the precise temporal dynamics by which water or food ingestion affect VPpp neuron activity, we directly recorded the spiking and calcium activity of genetically defined VPpp neurons. In states of elevated osmolality, water availability rapidly decreased VPpp neuron activity within seconds, beginning prior to water ingestion, upon presentation of water-predicting cues. In contrast, food availability following food restriction rapidly increased VPpp neuron activity within seconds, but only following feeding onset. These rapid and distinct changes in activity during drinking and feeding suggest diverse neural mechanisms underlying anticipatory regulation of VPpp neurons.

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《Neuron》 |2017年第1期|共9页
作者
Mandelblat-Cerf Yael; Kim Angela; Burgess Christian R.; Subramanian Siva; Tannous Bakhos A.; Lowell Bradford B.; Andermann Mark L.;
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作者单位

Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

Metab Boston MA 02215 USA;

Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

Metab Boston MA 02215 USA;

Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

Metab Boston MA 02215 USA;

Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

Metab Boston MA 02215 USA;

Harvard Med Sch Program Neurosci Boston MA 02115 USA;

Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

Metab Boston MA 02215 USA;

Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

Metab Boston MA 02215 USA;

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正文语种 eng
中图分类神经病学;
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10. Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons [O] . Yael Mandelblat-Cerf, Angela Kim, Christian R. Burgess, -1

机译：加压素神经元对未来渗透挑战的双向预期
11. Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons [O] . Yael Mandelblat-Cerf, Angela Kim, Christian R. Burgess, 2017

机译：对VasoPressin神经元未来渗透挑战的双向预期
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Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons

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