Highly selective brain-to-gut communication via genetically defined vagus neurons

Tao Jenkang; Campbell John N.; Tsai Linus T.; Wu Chen; Liberles Stephen D.; Lowell Bradford B.

首页> 外文期刊>Neuron >Highly selective brain-to-gut communication via genetically defined vagus neurons

【24h】

Highly selective brain-to-gut communication via genetically defined vagus neurons

机译：通过基因定义的迷走神经元具有高度选择性的脑 - 肠道通信

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The vagus nerve innervates many organs, and most, if not all, of its motor fibers are cholinergic. However, no one knows its organizing principles-whether or not there are dedicated neurons with restricted targets that act as "labeled lines"to perform certain functions, including two opposing ones (gastric contraction versus relaxation). By performing unbiased transcriptional profiling of DMV cholinergic neurons, we discovered seven molecularly distinct subtypes of motor neurons. Then, by using subtype-specific Cre driver mice, we show that two of these subtypes exclusively innervate the glandular domain of the stomach where, remarkably, they contact different enteric neurons releasing functionally opposing neurotransmitters (acetylcholine versus nitric oxide). Thus, the vagus motor nerve communicates via genetically defined labeled lines to control functionally unique enteric neurons within discrete subregions of the gastrointestinal tract. This discovery reveals that the parasympathetic nervous system utilizes a striking division of labor to control autonomic function.

机译：None

著录项

来源
《Neuron》 |2021年第13期|共15页
作者
Tao Jenkang; Campbell John N.; Tsai Linus T.; Wu Chen; Liberles Stephen D.; Lowell Bradford B.;
展开▼
作者单位

Harvard Med Sch Beth Israel Deaconess Med Ctr Dept Med Div Endocrinol Boston MA 02215 USA;

Harvard Med Sch Beth Israel Deaconess Med Ctr Dept Med Div Endocrinol Boston MA 02215 USA;

Harvard Med Sch Beth Israel Deaconess Med Ctr Dept Med Div Endocrinol Boston MA 02215 USA;

Harvard Med Sch Beth Israel Deaconess Med Ctr Dept Med Div Endocrinol Boston MA 02215 USA;

Harvard Med Sch Program Neurosci Boston MA 02115 USA;

Harvard Med Sch Beth Israel Deaconess Med Ctr Dept Med Div Endocrinol Boston MA 02215 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词

相似文献

外文文献
中文文献
专利

1. Effects of highly selective vagotomy plus resection of antral mucosa or highly selective vagotomy alone on motility function of pyloric antrum [J] . 文亚渊, 王代科, 刘宝华中国人民解放军军医大学学报（英文版） . 2004,第004期
2. Single-layer graphene as a highly selective barrier for vanadium crossover with high proton selectivity [J] . Saheed Bukola, Zhaodong Li, Jason Zack, 天然气化学（英文版） . 2021,第008期
3. Single-layer graphene as a highly selective barrier for vanadium crossover with high proton selectivity [J] . Saheed Bukola, Zhaodong Li, Jason Zack, 能源化学：英文版 . 2021,第008期
4. Catecholaminergic neurons in rat dorsal motor nucleus of vagus project selectively to gastric corpus. [J] . Guo JJ, Browning KN, Rogers RC, American Journal of Physiology . 2001,第3期

机译：大鼠迷走神经背运动核中的儿茶酚胺能神经元选择性地投射到胃体。
5. Pathways in gut-brain communication: Evidence for distinct gut-to-brain and brain-to-gut syndromes [J] . Keightley Philip C., Koloski Natasha A., Talley Nicholas J. The Australian and New Zealand journal of psychiatry . 2015,第3期

机译：Gut-Brain沟通的途径：明显的肠道对脑和脑与肠道综合征的证据
6. Tg(Th-Cre)FI172Gsat (Th-Cre) defines neurons that are required for full hypercapnic and hypoxic reflexes Tg(Th-Cre)FI172Gsat (Th-Cre) defines neurons that are required for full hypercapnic and hypoxic reflexes Tg(Th-Cre)FI172Gsat (Th-Cre) defines neurons that are required for full hypercapnic and hypoxic reflexes [J] . Russell S. Ray, Jenny J. Sun Biology Open . 2017,第8期

机译：Tg（Th-Cre）FI172Gsat（Th-Cre）定义完整的高碳酸血症和低氧反射所需的神经元Tg（Th-Cre）FI172Gsat（Th-Cre）定义完整的高碳酸血症和低氧反射所需的神经元Cre）FI172Gsat（Th-Cre）定义了充分的高碳酸血症和低氧反射所需的神经元
7. Photostimulation of sensory neurons of the rat vagus nerve [C] . Albert Y. Rhee, Gong Li, Jonathan Wells, Conference on Optical Interactions with Tissue and Cells; 20080121-23; San Jose,CA(US) . 2008

机译：大鼠迷走神经感觉神经元的光刺激
8. Single neurons in the macaque are selective for depth defined by motion parallax. [D] . Nadler, Jacob Ward. 2009

机译：猕猴中的单个神经元对运动视差定义的深度具有选择性。
9. The vagus nerves as seen in highly selective vagotomy. [O] . A. F. Robinson 1976

机译：在高度选择性迷走神经切断术中看到的迷走神经。
10. Alternative Paradigm of Selective Vagus Nerve Stimulation Tested on an Isolated Porcine Vagus Nerve [O] . Polona Pečlin, Janez Rozman 2014

机译：在孤立的猪迷走神经上测试了选择性迷走神经刺激的替代范式
11. Neuron Selectivity: Single Neuron and Neuron Networks [R] . Cooper, L. N., Munro, P., Scofield, C. 1982

机译：神经元选择性：单神经元和神经元网络

Highly selective brain-to-gut communication via genetically defined vagus neurons

摘要

著录项

相似文献

相关主题

期刊订阅