Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles

Vilcaes A. Alejandro; Chanaday Natali L.; Kavalali Ege T.

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Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles

机译：通过细胞外囊囊泡的综合释肽的可中性交换和功能整合

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Recent studies have investigated the composition and functional effects of extracellular vesicles (EVs) secreted by a variety of cell types. However, the mechanisms underlying the impact of these vesicles on neurotransmission remain unclear. Here, we isolated EVs secreted by rat and mouse hippocampal neurons and found that they contain synaptic-vesicle-associated proteins, in particular the vesicular SNARE (soluble N-ethylmaleimide-sensitive factor [NSF]-attachment protein receptor) synaptobrevin (also called VAMP). Using a combination of electrophysiology and live-fluorescence imaging, we demonstrate that this extracellular pool of synaptobrevins can rapidly integrate into the synaptic vesicle cycle of host neurons via a CD81-dependent process and selectively augment inhibitory neurotransmission as well as specifically rescue neurotransmission in synapses deficient in synaptobrevin. These findings uncover a novel means of interneuronal communication and functional coupling via exchange of vesicular SNAREs.

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《Neuron》 |2021年第6期|共19页
作者
Vilcaes A. Alejandro; Chanaday Natali L.; Kavalali Ege T.;
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Univ Nacl Cordoba CONICET Ctr Invest Quim Biol Cordoba CIQUIBIC X5000HUA Cordoba Argentina;

Vanderbilt Univ Dept Pharmacol Nashville TN 37240 USA;

Vanderbilt Univ Dept Pharmacol Nashville TN 37240 USA;

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正文语种 eng
中图分类神经病学;
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2. Progress in Understanding the Functional Roles of Extracellular Vesicles in Reproduction [J] . HAN Ting Ting, LI Wei, LI Guo Ping 生物医学与环境科学（英文版） . 2020,第007期
3. The emerging world of subcellular biological medicine: extracellular vesicles as novel biomarkers, targets, and therapeutics [J] . Leon G.ColemanJr 中国神经再生研究（英文版） . 2022,第005期
4. Extracellular vesicles drive tau spreading in Alzheimer 's disease [J] . Zhi Ruan 中国神经再生研究（英文版） . 2022,第002期
5. Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability [J] . Sharmila Bhattacharya, Bryan A. Stewart, Barbara A. Niemeyer, Proceedings of the National Academy of Sciences of the United States of America . 2002,第21期

机译：果蝇中突触臂蛋白/囊泡相关膜蛋白（VAMP）家族的成员在体内功能上可互换，以释放神经递质和细胞活力
6. The vesicle behind the fusion behind the transdifferentiation -functional RNA transfer from blood to brain by extracellular vesicles in inflammation [J] . Momma S. Acta physiologica . 2015,第Suppla699期

机译：转分化功能后的融合后的囊泡通过炎症中的细胞外囊泡从血液转移到大脑
7. Muscle functional recovery is driven by extracellular vesicles combined with muscle extracellular matrix in a volumetric muscle loss murine model [J] . Magarotto Fabio, Sgro Alberto, Dorigo Hochuli Agner Henrique, Biomaterials . 2021,第1期

机译：肌肉功能恢复是由细胞外囊与体积肌肉损失小鼠模型中的肌肉细胞外基质组合的
8. Enrichment of Extracellular Vesicles Via Lipid Nanoprobe-Functionalized Nanostructured Silica Microdevice [C] . Yuan Wan, Mackenzie Maurer, Hong-Zhang He, International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII . 2019

机译：通过脂质纳米探针功能化的纳米结构二氧化硅微器件富集细胞外囊泡。
9. Functional characterization of vesicle-snares in GLUT4 glucose transporter vesicle traffic. [D] . Randhawa, Varinder Kaur. 2002

机译：GLUT4葡萄糖转运蛋白囊泡运输中囊泡的功能表征。
10. From the Cover: Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability [O] . Sharmila Bhattacharya, Bryan A. Stewart, Barbara A. Niemeyer, 2002

机译：从封面开始：果蝇中突触连接蛋白/囊泡相关膜蛋白（VAMP）家族的成员在体内功能上可互换以释放神经递质和细胞活力
11. Vesicle-associated membrane protein (VAMP)/synaptobrevin-2 protein mutants functionality test in synaptic vesicle fusion [O] . Praggastis Sophia 2014

机译：突触囊泡融合中的囊泡相关膜蛋白（VAMP）/ synaptobrevin-2蛋白突变体功能测试
12. Role of Extracellular Vesicles in Metastasis. [R] . Loots, G. G. 2017

机译：细胞外囊泡在转移中的作用。

Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles

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