Emergence of Neuronal Diversity during Vertebrate Brain Development

Raj Bushra; Farrell Jeffrey A.; Liu Jialin; El Kholtei Jakob; Carte Adam N.; du Lucia Y.; McKenna Aaron; Relic Dorde; Leslie Jessica M.; Schier Alexander F.; Acedo Joaquin Navajas

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Emergence of Neuronal Diversity during Vertebrate Brain Development

机译：脊椎动物脑发育中神经元多样性的出现

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Neurogenesis comprises many highly regulated processes including proliferation, differentiation, and maturation. However, the transcriptional landscapes underlying brain development are poorly characterized. We describe a developmental single-cell catalog of similar to 220,000 zebrafish brain cells encompassing 12 stages from embryo to larva. We characterize known and novel gene markers for similar to 800 clusters and provide an overview of the diversification of neurons and progenitors across these time points. We also introduce an optimized GESTALT lineage recorder that enables higher expression and recovery of Cas9-edited barcodes to query lineage segregation. Cell type characterization indicates that most embryonic neural progenitor states are transitory and transcriptionally distinct from neural progenitors of post-embryonic stages. Reconstruction of cell specification trajectories reveals that late-stage retinal neural progenitors transcriptionally overlap cell states observed in the embryo. The zebrafish brain development atlas provides a resource to define and manipulate specific subsets of neurons and to uncover the molecular mechanisms underlying vertebrate neurogenesis.

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《Neuron》 |2020年第6期|共24页
作者
Raj Bushra; Farrell Jeffrey A.; Liu Jialin; El Kholtei Jakob; Carte Adam N.; du Lucia Y.; McKenna Aaron; Relic Dorde; Leslie Jessica M.; Schier Alexander F.; Acedo Joaquin Navajas;
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作者单位

Harvard Univ Dept Mol &

Cellular Biol Cambridge MA 02138 USA;

Harvard Univ Dept Mol &

Cellular Biol Cambridge MA 02138 USA;

Allen Discovery Ctr Cell Lineage Tracing Seattle WA 98195 USA;

Allen Discovery Ctr Cell Lineage Tracing Seattle WA 98195 USA;

Harvard Univ Dept Mol &

Cellular Biol Cambridge MA 02138 USA;

Allen Discovery Ctr Cell Lineage Tracing Seattle WA 98195 USA;

Dartmouth Geisel Sch Med Dept Mol &

Syst Biol Lebanon NH 03756 USA;

Univ Basel Biozentrum CH-4056 Basel Switzerland;

Harvard Univ Dept Mol &

Cellular Biol Cambridge MA 02138 USA;

Harvard Univ Dept Mol &

Cellular Biol Cambridge MA 02138 USA;

Allen Discovery Ctr Cell Lineage Tracing Seattle WA 98195 USA;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
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Emergence of Neuronal Diversity during Vertebrate Brain Development

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