Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury

Niehaus Jesse K.; Taylor-Blake Bonnie; Loo Lipin; Simon Jeremy M.; Zylka Mark J.

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Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury

机译：脊柱巨噬细胞在外周损伤后解决了伤害性超敏反应

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Peripheral nerve injury induces long-term pro-inflammatory responses in spinal cord glial cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal inflammation has not been determined. Guided by single-cell RNA sequencing (scRNA-seq), we found that MRC1(+) spinal cord macrophages proliferated and upregulated the anti-inflammatory mediator Cd163 in mice following superficial injury (SI; nerve intact), but this response was blunted in nerve-injured animals. Depleting spinal macrophages in SI animals promoted microgliosis and caused mechanical hypersensitivity to persist. Conversely, expressing Cd163 in spinal macrophages increased Interleukin 10 expression, attenuated micro- and astrogliosis, and enduringly alleviated mechanical and thermal hypersensitivity in nerve-injured animals. Our data indicate that MRC1(+) spinal macrophages actively restrain glia to limit neuroinflammation and resolve mechanical pain following a superficial injury. Moreover, we show that spinal macrophages from nerve-injured animals mount a dampened anti-inflammatory response but can be therapeutically coaxed to promote long-lasting recovery of neuropathic pain.

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《Neuron》 |2021年第8期|共15页
作者
Niehaus Jesse K.; Taylor-Blake Bonnie; Loo Lipin; Simon Jeremy M.; Zylka Mark J.;
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作者单位

Univ N Carolina UNC Neurosci Ctr Chapel Hill NC 27599 USA;

Univ N Carolina Dept Cell Biol &

Physiol Chapel Hill NC 27599 USA;

Univ N Carolina Dept Cell Biol &

Physiol Chapel Hill NC 27599 USA;

Univ N Carolina Dept Genet Chapel Hill NC 27599 USA;

Univ N Carolina UNC Neurosci Ctr Chapel Hill NC 27599 USA;

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正文语种 eng
中图分类神经病学;
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Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury

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