Subcellular specificity of cannabinoid effects in striatonigral circuits

Soria-Gomez Edgar; Zottola Antonio C. Pagano; Mariani Yamuna; Desprez Tifany; Barresi Massimo; Bonilla-del Rio Itziar; Muguruza Carolina; Le Bon-Jego Morgane; Julio-Kalajzic Francisca; Flynn Robyn; Terral Geoffrey; Fernandez-Moncada Ignacio; Robin Laurie M.; da Cruz Jose F. Oliveira; Corinti Simone; Amer Yasmine Ould; Goncalves Julia; Varilh Marjorie; Cannich Astrid; Redon Bastien; Zhao Zhe; Leste-Lasserre Thierry; Vincent Peggy; Tolentino-Cortes Tarson; Busquets-Garcia Arnau; Puente Nagore; Bains Jaideep S.; Hebert-Chatelain Etienne; Barreda-Gomez Gabriel; Chaouloff Francis; Lohman Alexander W.; Callado Luis F.; Grandes Pedro; Baufreton Jerome; Marsicano Giovanni; Bellocchio Luigi

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Subcellular specificity of cannabinoid effects in striatonigral circuits

机译：斯特纳替突电路中大麻素作用的亚细胞特异性

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Recent advances in neuroscience have positioned brain circuits as key units in controlling behavior, implying that their positive or negative modulation necessarily leads to specific behavioral outcomes. However, emerging evidence suggests that the activation or inhibition of specific brain circuits can actually produce multimodal behavioral outcomes. This study shows that activation of a receptor at different subcellular locations in the same neuronal circuit can determine distinct behaviors. Pharmacological activation of type 1 cannabinoid (CB1) receptors in the striatonigral circuit elicits both antinociception and catalepsy in mice. The decrease in nociception depends on the activation of plasma membrane-residing CB1 receptors (pmCB1), leading to the inhibition of cytosolic PKA activity and substance P release. By contrast, mitochondrial-associated CB1 receptors (mtCB1) located at the same terminals mediate cannabinoid-induced catalepsy through the decrease in intra-mitochondrial PKA-dependent cellular respiration and synaptic transmission. Thus, subcellular-specific CB1 receptor signaling within striatonigral circuits determines multimodal control of behavior.

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来源
《Neuron》 |2021年第9期|共25页
作者
Soria-Gomez Edgar; Zottola Antonio C. Pagano; Mariani Yamuna; Desprez Tifany; Barresi Massimo; Bonilla-del Rio Itziar; Muguruza Carolina; Le Bon-Jego Morgane; Julio-Kalajzic Francisca; Flynn Robyn; Terral Geoffrey; Fernandez-Moncada Ignacio; Robin Laurie M.; da Cruz Jose F. Oliveira; Corinti Simone; Amer Yasmine Ould; Goncalves Julia; Varilh Marjorie; Cannich Astrid; Redon Bastien; Zhao Zhe; Leste-Lasserre Thierry; Vincent Peggy; Tolentino-Cortes Tarson; Busquets-Garcia Arnau; Puente Nagore; Bains Jaideep S.; Hebert-Chatelain Etienne; Barreda-Gomez Gabriel; Chaouloff Francis; Lohman Alexander W.; Callado Luis F.; Grandes Pedro; Baufreton Jerome; Marsicano Giovanni; Bellocchio Luigi;
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作者单位

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

Univ Bordeaux Bordeaux France;

Univ Basque Country UPV EHU Fac Med &

Nursing Dept Neurosci Leioa Spain;

Univ Basque Country UPV EHU Dept Pharmacol Leioa Spain;

Univ Bordeaux Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

Univ Calgary Cumming Sch Med Dept Cell Biol &

Anat Calgary AB Canada;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

Univ Moncton Dept Biol Canada Res Chair Mitochondrial Signaling &

Physio Moncton NB Canada;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

Univ Basque Country UPV EHU Fac Med &

Nursing Dept Neurosci Leioa Spain;

Univ Calgary Hotchkiss Brain Inst Calgary AB Canada;

Univ Moncton Dept Biol Canada Res Chair Mitochondrial Signaling &

Physio Moncton NB Canada;

IMG Pharma Biotech SL Dept Res &

Dev Derio Spain;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

Univ Calgary Hotchkiss Brain Inst Calgary AB Canada;

Univ Basque Country UPV EHU Dept Pharmacol Leioa Spain;

Univ Basque Country UPV EHU Fac Med &

Nursing Dept Neurosci Leioa Spain;

Univ Bordeaux Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

INSERM NeuroCtr Magendie Endocannabinoids &

Neuroadaptat U1215 Bordeaux France;

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正文语种 eng
中图分类神经病学;
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Subcellular specificity of cannabinoid effects in striatonigral circuits

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