Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

Shipley Frederick B.; Dani Neil; Xu Huixin; Deister Christopher; Cui Jin; Head Joshua P.; Sadegh Cameron; Fame Ryann M.; Shannon Morgan L.; Flores Vanessa I.; Kishkovich Thomas; Jang Emily; Klein Eric M.; Goldey Glenn J.; He Kangmin; Zhang Yong; Holtzman Michael J.; Kirchhausen Tomas; Wyart Claire; Moore Christopher I.; Andermann Mark L.; Lehtinen Maria K.

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Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

机译：脉络丛血脑脊髓液界面跟踪钙动力学和免疫监测

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The choroid plexus (ChP) epithelium is a source of secreted signaling factors in cerebrospinal fluid (CSF) and a key barrier between blood and brain. Here, we develop imaging tools to interrogate these functions in adult lateral ventricle ChP in whole-mount explants and in awake mice. By imaging epithelial cells in intact ChP explants, we observed calcium activity and secretory events that increased in frequency following delivery of serotonergic agonists. Using chronic two-photon imaging in awake mice, we observed spontaneous subcellular calcium events as well as strong agonist-evoked calcium activation and cytoplasmic secretion into CSF. Three-dimensional imaging of motility and mobility of multiple types of ChP immune cells at baseline and following immune challenge or focal injury revealed a range of surveillance and defensive behaviors. Together. these tools should help illuminate the diverse functions of this understudied body-brain interface.

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《Neuron》 |2020年第4期|共27页
作者
Shipley Frederick B.; Dani Neil; Xu Huixin; Deister Christopher; Cui Jin; Head Joshua P.; Sadegh Cameron; Fame Ryann M.; Shannon Morgan L.; Flores Vanessa I.; Kishkovich Thomas; Jang Emily; Klein Eric M.; Goldey Glenn J.; He Kangmin; Zhang Yong; Holtzman Michael J.; Kirchhausen Tomas; Wyart Claire; Moore Christopher I.; Andermann Mark L.; Lehtinen Maria K.;
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作者单位

Boston Childrens Hosp Dept Pathol Boston MA 02115 USA;

Boston Childrens Hosp Dept Pathol Boston MA 02115 USA;

Boston Childrens Hosp Dept Pathol Boston MA 02115 USA;

Brown Univ Carney Inst Brain Sci Providence RI 02912 USA;

Boston Childrens Hosp Dept Pathol Boston MA 02115 USA;

Boston Childrens Hosp Dept Pathol Boston MA 02115 USA;

Boston Childrens Hosp Dept Pathol Boston MA 02115 USA;

Boston Childrens Hosp Dept Pathol Boston MA 02115 USA;

Boston Childrens Hosp Dept Pathol Boston MA 02115 USA;

Beth Israel Deaconess Med Ctr Dept Med Div Endocrinol Diabet &

Metab Boston MA 02115 USA;

Brown Univ Carney Inst Brain Sci Providence RI 02912 USA;

Brown Univ Carney Inst Brain Sci Providence RI 02912 USA;

Brown Univ Carney Inst Brain Sci Providence RI 02912 USA;

Beth Israel Deaconess Med Ctr Dept Med Div Endocrinol Diabet &

Metab Boston MA 02115 USA;

Harvard Med Sch Program Cellular &

Mol Med Boston Childrens Hosp Dept Cell Biol Boston MA;

Washington Univ Dept Med Pulm &

Crit Care Med St Louis MO 63110 USA;

Washington Univ Dept Med Pulm &

Crit Care Med St Louis MO 63110 USA;

Harvard Med Sch Program Cellular &

Mol Med Boston Childrens Hosp Dept Cell Biol Boston MA;

Sorbonne Univ Inst Cerveau &

Moelle Epiniere ICM Inserm U1127 CNRS UMR 7225 F-75013 Paris;

Brown Univ Carney Inst Brain Sci Providence RI 02912 USA;

Harvard Univ Grad Program Biophys Cambridge MA 02138 USA;

Boston Childrens Hosp Dept Pathol Boston MA 02115 USA;

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正文语种 eng
中图分类神经病学;
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5. Effects of Interfaces on Dynamics in Micro-Fluidic Devices: Slip-Boundaries' Impact on Rotation Characteristics of Polar Liquid Film Motors [J] . Su-Rong Jiang, Zhong-Qiang Liu, Tamar Amos Yinnon, 理论物理通讯（英文版） . 2017,第005期
6. Oxidative stress in the choroid plexus contributes to blood-cerebrospinal fluid barrier disruption during sepsis development [J] . Goldim Mariana Pereira, Danielski Lucineia Gainski, Rodrigues Judite Filgueiras, Microvascular Research: An International Journal . 2019,第期

机译：脉络膜丛中的氧化应激有助于败血症发育过程中的血液脑脊液屏障破坏
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机译：人脉络丛乳头状瘤细胞系HIBCPP外排转运蛋白的特征，HIBCPP是血脑脊液屏障的功能性体外模型
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机译：在嵌入式/浸入式边界方法中跟踪动态流体结构界面的计算算法
10. PHOSPHOINOSITIDE HYDROLYSIS AS AN EFFECTOR SYSTEM OF CENTRAL SEROTONIN RECEPTORS (CHOROID PLEXUS, CEREBROSPINAL FLUID, CEREBRAL CORTEX, PHOSPHATIDYLINOSITOL HYDROLYSIS, SEROTONIN ANTAGONISTS). [D] . CONN, P. JEFFREY. 1986

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13. S-Band Range Tracker and Surveillance Lab Interface [R] . Bush, B. D. 1983

机译：s波段跟踪器和监视实验室接口

Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

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